Incidence of Pediatric, Adolescent and Young Adult Head and Neck Melanoma is on the Rise

Incidence of the pediatric, teen, and young adult head and neck melanoma in North America appears to have grown by 51.1 percent in the past two decades, reports a new study.

Head and neck melanoma among pediatric, adolescent, and young adult populations in the U.S. and Canada increased by 51.1 percent from 1995 to 2014, reveals a new study. The findings of the study are pulished in the journal JAMA Otolaryngology.//

In the U.S., melanoma is the fifth most commonly diagnosed cancer in both males and females; in Canada, it is the seventh most commonly diagnosed cancer. Between 18-22 percent of new melanoma cases, a type of skin cancer, are found in the head and neck region.

Melanoma - Causes, Symptoms, Diagnosis, Treatment & Prevention
Melanoma of the skin is a dangerous type of skin cancer that usually appears as a cancerous mole due to exposure to the sun’s damaging UV rays.

‘The incidence of melanoma was higher among males than females, especially among white males. ’

"The team was driven by two things. First, although only one in five melanoma cases happen in the head and neck region, head and neck melanoma has worse survival rates compared to other regions of the body," Osazuwa-Peters said. "In fact, the five-year survival rate of head and neck melanoma is worse than the 10-year survival rates of other regions of the body.

"Second, although melanoma is diagnosed on the average at age 63, the main risk factors for cancer, especially sun exposure and use of indoor tanning, are most common among adolescents and young adults."

Patients from the North American Association of Central Cancer Registries' Cancer in North America (CiNA) public data set were included in this study. The study population looked at patients from infancy to 39 years of age, diagnosed with head and neck melanoma between 1995 and 2014.

Subungual Melanoma | Fingernail Cancer - Causes, Symptoms, Diagnosis, Treatment and Prevention
Subungual (below the nail) melanoma is a rare skin cancer that develops due to activated pigment-producing cells. A brown-black longitudinal band is a typical sign of nail cancer.

There were 12,462 patients diagnosed with head and neck melanoma in the U.S. and Canada during the study's time frame; of those, 6,810 cases (54.6 percent) occurred in male patients. Most cases - 11,342 or 91 percent - resided in the United States.

In both countries, the skin of the neck and scalp was the area where the most head and neck melanoma were diagnosed. The skin of the lip was the least diagnosed area. Melanoma of the external ear, skin of other parts of the face and the skin of the scalp and neck were all more likely to be diagnosed than that of the skin of the lip.

Melanoma Treatment - New Investigational Drug Shows Promise in Early Phase I Clinical Trials
Novel compound dubbed MK-8353 offers hope in the treatment of melanoma and other cancers with mutations in BRAF or RAS genes in early phase I clinical trials

"This is the first study of the head, and neck melanoma in adolescents and young adults in the United States and Canada combined," Osazuwa-Peters said. "While we found a 51 percent increase in incidence during the last two decades in our study, another important finding is that incidence was greater among males than females, especially among white males."

In the United States, non-Hispanic white patients had the highest age-adjusted incident rates of melanoma, while non-Hispanic black or other race patients had the lowest AAIR.

Obesity Prolongs Life For Men With Metastatic Melanoma
Men with metastatic melanoma have a better survival rate if they are obese as they respond better to immunotherapy.

In both countries combined, the age-adjusted incidence of head and neck melanoma increased 3.71 percent yearly from 1995 to 2001 and 1.21 percent yearly from 2001 to 2014.

"This is an important finding because melanoma in other parts of the body are usually more common in females than males," Osazawa-Peters said. "It is, therefore, important that melanoma prevention campaigns do not only focus on young women."

The data set comprises registries within the National Program of Cancer Registries; the Cancer Committee at the Center for Cancer Care and Research Provincial and Territorial Registries; National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER); and the North American Association of Central Cancer Registry. Current CiNA data includes 93 percent of the U.S. population and 64 percent of the Canadian population.

The research was limited by its inability to make causal inferences from retrospective data. Also, the Canadian data lacked racial/ethnic identifiers, which meant that no racial/ethnic information could be drawn.

"There is room for the lay public to help in early detection," Osazuwa-Peters said. "For example, barbers and stylists might be the first to spot irregular skin on the scalp before the doctors do. It is, therefore, important to increase awareness about this cancer. This is in support of the ABCDE campaign that was initiated by experts over 30 years ago, which had the goal of increasing lay public's recognition of early signs of melanoma."

Source-Eurekalert