Indicators to Reaction to Medication in Juvenile Arthritis Treatment, Identified

Response to etanercept treatment is more likely in juvenile idiopathic arthritis (JIA) patients, recent study identifies.

It found that patients who had with low measures of disability at study entry, younger age at the onset of JIA, and fewer disease-modifying antirheumatic, drugs used before initiating etanercept achieved an excellent response to the treatment.

Reactive Arthritis - Symptoms - Causes - Diagnosis - Treatment
Reactive arthritis is an autoimmune condition. Ankylosing spondylitis, psoriatic arthritis are disorders associated with Reactive arthritis.

The U.S. Food and Drug Administration and the European Medicines Agency for the treatment of JIA approved Etanercept a decade ago.

"The ability to identify patients who are more likely to respond to etanercept treatment would be an important step toward tailored patient-specific treatment and subsequently could improve current treatment approaches," according to the researchers.

Marieke H. Otten, M.D., M.Sc., of the Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands, and colleagues conducted a study to evaluate JIA disease activity after beginning treatment with etanercept and to identify characteristics associated with treatment response.

Osteoarthritis - Causes, Symptoms, DIagnosis, Treatment, FAQs
Osteoarthritis is one of the commonest joint disorder and occurs as we age due to wear and tear of a joint. Osteoarthritis can affect any joint of the body.

The researchers used data from the Arthritis and Bioiogicals in Children Register, an ongoing prospective observational study since 1999, which includes all Dutch JIA patients who received biologic agents.

For this study, response to treatment was evaluated 15 months after initiation of etanercept.

Oligoarthritis | Children and Arthritis - Types, Diagnosis, Treatment
Most parents when told that their child has arthritis find it hard to believe it, as arthritis is regarded an adult's disease.

Of the 262 patients, 85 were considered excellent responders after 15 months of treatment; a total of 85 patients were considered poor responders; and the remaining 92 patients were considered intermediate responders.

Compared with achieving an intermediate or poor response, achievement of an excellent response was associated with lower scores on measures of disability at study entry; low number of DMARDs (including methotrexate) used before introduction of etanercept; and younger age at onset.

Modified Footwear may Help Protect Knee from Further Damage in Arthritis
Wearing modified shoes while walking will help reduce the risk of further damage to the knees among patients suffering from knee osteoarthritis

Compared with achieving an intermediate or excellent response, achievement of a poor response was associated with systemic JIA and female sex.

During etanercept treatment, patients experienced a total of 31 serious, 99 infectious, and 179 noninfectious adverse events.

The study has been published in JAMA.

Source-ANI