Inflammation Impacts Weight Loss Post Bariatric Surgery

In obese patients undergoing weight-loss surgery, higher blood levels of inflammation are associated with poor weight loss post-surgery.

Higher blood levels of inflammation in obese patients undergoing bariatric (weight-loss) surgery were found to have poor weight loss in six months after the procedure. This study was led by researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London, and published in Psychological Medicine ().

Inflammation Linked to Bariatric Surgery Outcomes

Obesity costs the NHS around £6 billion a year, and this figure is predicted to rise to £9.6 billion per year by 2050. Bariatric surgery physically alters the stomach and/or the bowel to reduce the amount of food people can eat and to reduce the absorption of nutrients.

Obese patients can lose up to 70 percent of excess weight after surgery but there is variation in the outcomes. To help patients with obesity and ensure costly treatments are as effective as possible (private bariatric surgery can cost £4,000 to £10,000), it is important to understand the factors that can influence surgery.

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The analysis showed a strong relationship between depression and inflammation in obese patients before and after surgery and it indicated that it was increased inflammation, rather than depression that was driving poor weight loss after bariatric surgery.

Analyzing Immune Response Post-Bariatric Surgery

Depression and obesity are known to often occur together, and previous research suggests the release of inflammatory proteins as part of the immune response may be a shared disease mechanism that is driving both conditions.

To improve the understanding of this relationship and its potential role in obesity and bariatric surgery outcomes, the study investigated the differences in proteins released in the body during inflammation between obese patients with and without depression undergoing surgery.

The 85 participants in the study, enrolled from King’s College Hospital NHS Foundation Trust in south London, were all obese (BMI >35) and part of the ongoing Bariatric Surgery & Depression study. Levels of proteins released during inflammation, such as C-Reactive Protein (CRP) and cytokines, such as interleukin-6 (IL-6) and interleukin-4 (IL-4), were measured before and after surgery in participants’ blood and tissue.

Before surgery, 41 participants had symptoms of depression that reached the threshold of a clinical diagnosis, while in the remaining 44 participants, the symptoms of depression were below this threshold. The study showed that those with depression had higher levels of the inflammatory proteins CRP and IL-6 in the blood and lower levels of the anti-inflammatory protein IL-4. They also had higher levels of one inflammatory protein in their adipose tissue.

Six months after surgery, the bariatric patients who had depression before surgery continued to have higher levels of IL-6 and CRP in the blood, despite no difference in weight loss between those with and without depression.

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Out of 44 patients who had depression before surgery, 29 completed the six-month follow-up and only about one-third (34.5 percent;10 patients) of those still had clinical depression after surgery.

Researchers analyzed whether measures of inflammation and depression before surgery might be able to predict weight loss and depression after surgery. This showed that higher levels of CRP predicted reduced weight loss at six-month follow-up. However, levels of CRP in the blood before surgery did not predict levels of depression afterwards; instead, this was predicted by depression before surgery and experience of childhood trauma.

Reference:

Peripheral inflammation associated with depression and reduced weight loss: a longitudinal study of bariatric patients- (https://www.cambridge.org/core/journals/psychological-medicine/article/peripheral-inflammation-associated-with-depression-and-reduced-weight-loss-a-longitudinal-study-of-bariatric-patients/3427098C0DDD66137724B8C865A6CC2D)

Source: Eurekalert