Innovative Treatment for Protecting People With Peanut Allergy

A new treatment on protecting people having peanut allergy was found. Developing tolerance to peanuts over a period of time can help get rid of severity in symptoms upon accidental ingestion.

Some people having peanut allergy can protect themselves from accidental ingestion by building their tolerance towards peanuts over a period of time. The findings of the new study were published in the New England Journal of Medicine.//

"We're excited about the potential to help children and adolescents with peanut allergy protect themselves against accidentally eating a food with peanut in it," says allergist Stephen Tilles, MD, ACAAI past president, study co-author, and consulting advisor for Aimmune Therapeutics. "Our hope when we started the study was that by treating patients with the equivalent of one peanut per day, many would tolerate as much as two peanuts. We were pleased to find that two thirds of the people in the study were able to tolerate the equivalent of two peanuts per day after nine to 12 months of treatment, and half the patients tolerated the equivalent of four peanuts."

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‘‘There is no treatment available for peanut allergy. Once this treatment is approved by the FDA, people with peanut allergy can stay protected by following it’.’

Study participants ranged in age from 4 to 55 years, most were 4 to 17, and all had peanut allergy. One third of the participants were given a placebo, while the remaining two-thirds were given peanut protein powder in increasing amounts until reaching the "maintenance dose" - the dose they stayed on for the remainder of the study. The maintenance does was the equivalent of one peanut daily.

"This is not a quick fix, and it doesn't mean people with peanut allergy will be able to eat peanuts whenever they want," says allergist Jay Lieberman, MD, vice chair of the ACAAI Food Allergy Committee and study co-author. "But it is definitely a breakthrough. The hope would be to have a treatment available in the second half of 2019. If that happens, people who receive and are able to tolerate this treatment should be protected from accidental exposures."

All those in the study received peanut protein as part of an oral food challenge (OFC). A person in an OFC is given a very small dose of the food by mouth under the supervision of a board-certified allergist to test for a severe reaction. OFCs are considered the gold standard for testing food allergy.

"Reactions from the oral challenges at the end of the study were much milder than prior to treatment," says Dr. Tilles. "On average, the participants were able to tolerate a 100-fold higher dose of peanut at the end of the study than they did at the beginning. In addition, the symptoms caused by the 100-fold higher dose at the end of study were milder than the symptoms on the lower dose at the beginning of the study."

Facts about this pivotal study

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• More participants and more detailed data than all prior oral immunotherapy studies combined

• Fewer severe allergic reactions requiring epinephrine during oral food challenges

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• Fewer side effects than anticipated - e.g. only six percent dropped out of the study due to gastrointestinal side effects; Also, one-third of patients completed the study with no more than mild side effects along the way.

• 80 percent of participants successfully reached daily maintenance dose of the equivalent of one peanut.

There are currently no approved treatment options for peanut allergy. If this treatment is approved by the FDA, it will be available by prescription, and people with peanut allergy will need to remain on it to stay protected against accidental consumption. Once someone stops the treatment, there is no longer a protective effect.

Source-Eurekalert