Is Preterm Birth Linked to Autism?

Explore the absence of association between preterm birth and autism, in contrast to the findings of previous studies.

Earlier research suggests that there is a link between preterm birth and autism. In contrast, a recent study presented at the Society for Maternal-Fetal Medicine’s (SMFM) annual meeting, The Pregnancy Meeting, reveals findings indicating there is no significant association between preterm birth and autism ().

New Study Debunks Preterm Birth-Autism Connection

Autism, also known as Autism Spectrum Disorder (ASD), is one of the most common developmental disorders and is increasingly diagnosed worldwide. According to the World Health Organization, an estimated one in 100 children has autism. In the U.S., those numbers are much higher, with an estimated one in 36 children being diagnosed with autism, according to the Centers for Disease Control and Prevention.

Researchers analyzed nearly 115,000 deliveries over 12 years from 2005-2017 using records from hospital and community clinics in Israel. Data encompassed a wide diversity of pregnant people that included Jewish and Muslim people as well as Bedouins, a minority group within the Muslim community who lead a nomadic or semi-nomadic life.

Quiz on Autism
Autism spectrum disorder is a complex genetic disorder that impairs social, behavioral, and communication functions in humans. Autistic people may act, communicate, interact, and learn differently than most other people. ASD usually begins in childhood and can last for the rest of a person's life, though symptoms may improve over time

‘There is no substantial link between preterm birth and autism after adjusting for factors like ethnicity and maternal age. #pretermbirth #autism #childbirth #medindia ’

The study looked at the diagnosis of autism in children based on when infants were delivered: extremely preterm, very preterm, moderate to late preterm, or term.

Of the 114,975 pregnancies analyzed, 0.3 percent of newborns were delivered extremely preterm, or before 28 weeks; 0.6 percent were delivered very preterm, or between 28 to just under 32 weeks; 6 percent were delivered moderate to late preterm, or between 32 to just under 37 weeks; and the remaining 93.1 percent were delivered at term, or between 37 weeks to 42 weeks.

In the initial analysis, researchers found a significant association between preterm delivery and the occurrence of autism (1.6% percent vs. 0.3 percent vs. 0.8 percent vs. 0.7 percent for extremely preterm, very preterm, moderate to late preterm, and term deliveries, respectively).

Autism Causes, Symptoms, Diagnosis, Treatment, Prognosis
Autism is a neurodevelopmental disorder typically characterized by impaired social and communication skills combined with repetitive movements.

Nevertheless, after advanced analysis adjusting for factors that could potentially be associated with autism, such as ethnicity, small for gestational age, maternal age, and the infant’s gender, researchers found no significant association between preterm delivery and autism.

“The exact cause of autism is complex,” says the study’s lead author Sapir Ellouk, MD, MPH, an obstetrics and gynecology resident at Soroka Medical Center’s Saban Maternity and Birthing Center in Beer-Sheva, HaDarom, Israel. “But based on our data, a single obstetric factor is unlikely to be the cause of ASD. A more plausible theory involves the simultaneous presence of multiple factors.”

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Reference:

23 Investigating the Association between Preterm Delivery and Autism Spectrum Disorder in Childhood - (https://www.ajog.org/article/S0002-9378(23)00841-4/fulltext)

Source-Eurekalert

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