The study findings help redefine osteoarthritis as a reversible loss of key cartilage stem cells, not just 'wear and tear'."
Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis
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Osteoarthritis: Fresh Insights
Osteoarthritis is the degeneration of cartilage and other tissues in joints and is the most common form of arthritis. Current osteoarthritis treatment manages symptoms rather than addressing the underlying disease. It is a long-term and progressive condition which affects people's mobility and has historically had no cure. Often described as a 'wear and tear' condition, factors such as ageing, obesity, injury and family history contribute to the progression of osteoarthritis. The study by researchers at the University of Adelaide showed the condition may be treatable and reversible.Gremlin 1 Cells: Pioneering Cartilage Regeneration Beyond Osteoarthritis
Gremlin 1 cells present opportunities for cartilage regeneration and their discovery will have relevance to other forms of cartilage injury and disease, which are notoriously challenging to repair and treat. It challenges the categorization of osteoarthritis as wear and tear.
Hip replacement
Are you experiencing pain due to damaged hips? Travel abroad to get replacement surgery at affordable prices.
Are you experiencing pain due to damaged hips? Travel abroad to get replacement surgery at affordable prices.
‘Fibroblast growth factor 18 (FGF18) activated Gremlin 1 stem cells in mice's joint cartilage, significantly increasing cartilage thickness and reducing osteoarthritis. #arthritis #stemcells’
"With this new information, we are now able to explore pharmaceutical options to directly target the stem cell population that is responsible for the development of articular cartilage and progression of osteoarthritis," Ng said. While the discovery, published in the journal Nature Communications, is limited to animal models, Dr. Ng said there are genetic similarities to human samples, and human trials are ongoing."We look forward to the outcome of these trials and to contribute to the better understanding of a pharmaceutical mechanism to treat osteoarthritis," she said.
Reference:
- Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis - (https://www.nature.com/articles/s41467-023-42199-1)
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Osteoarthritis
Osteoarthritis is one of the commonest joint disorder and occurs as we age due to wear and tear of a joint. Osteoarthritis can affect any joint of the body.
Osteoarthritis is one of the commonest joint disorder and occurs as we age due to wear and tear of a joint. Osteoarthritis can affect any joint of the body.
Quiz on Stem Cells
Scientists believe (and are working hard) to use stem cells in the future to treat a wide range of diseases and injuries. But what exactly is a stem cell? How can it be used in curing disorders? See if you get your answers from this ...
Scientists believe (and are working hard) to use stem cells in the future to treat a wide range of diseases and injuries. But what exactly is a stem cell? How can it be used in curing disorders? See if you get your answers from this ...
Top Foods for Strong Bones
As we get older, our bones start becoming weak, especially in women after menopause. To keep your bones strong, here is the list of recommended top foods.
As we get older, our bones start becoming weak, especially in women after menopause. To keep your bones strong, here is the list of recommended top foods.
