Kids Who Start Drinking Booze Before 15 may Have Memory Issues Later On

If kids before the age 15 start drinking booze it will affect their memory very early, finds a new study.

Drinking booze before the age of 15 can affect kids memory negatively, finds a new study. The findings of this study are published in the Journal of Neuroscience. This study discusses the how drinking booze can impair working memory of children.

A new study from researchers at Columbia University Irving Medical Center found that binge drinking impairs working memory in the adolescent brain. The study, in mice, explains why teenagers who binge drink are 15 times more likely to become alcoholics during adulthood.

Binge Drinking in Early 20s can Alter Brain Functioning
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‘Most adults with alcohol addiction begin their excessive drinking as teenagers. To find ways to prevent or treat these disorders, it's important to understand not only the social and environmental factors that contribute to early binge drinking, but also the changes that occur in the brain that lead to alcohol addiction.’

"The brains of young teens are at a stage of development that makes them more vulnerable to being switched on to alcohol addiction," says Neil Harrison, Ph.D., professor of anesthesiology and pharmacology at Columbia University Vagelos College of Physicians and Surgeons (VP&S) who researches the effects of alcohol on the brain. "The question we're asking is, can we find those switches in the adolescent binge drinker so that we can turn it off?"

Other researchers have looked at the neuroscience of binge drinking--by getting mice intoxicated through vapor inhalation or alcohol injection. Michael Salling, Ph.D., assistant professor of anesthesiology at VP&S, and his team are taking a different approach, allowing the mice to drink voluntarily.

"Shortcuts are useful in getting animals to drink, but these models don't resemble how drinking develops in humans," Harrison says. In Salling's approach, mice are given access to alcohol every other day during a period in their development that's equivalent to human adolescence. "Some of the mice drink avidly and some very little--which parallels the human experience."

Binge Drinking in Teens May Affect Short-Term Memory
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The consequences of binge drinking in adolescent mice are also similar to the effects in humans. As the mice become young adults, those that drank heavily in their youth adopt drinking patterns often seen in people.

"Often the mice will drink robustly as soon as the alcohol is provided," says Salling. "This so-called front-loading behavior is frequently present in people who later develop an alcohol use disorder."

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The most striking changes the researchers saw appeared in neurons within the mouse equivalent of the human prefrontal cortex (PFC), which is involved in planning actions by suppressing inappropriate responses and maintaining working memory (which governs very short-term memory) and attention. The area does not completely mature in people until their 20s.

In the binge-drinking mice, certain PFC neurons were less able to generate persistent activity, and these changes appear to impair working memory. This finding is consistent with imaging studies that show decreased resting activity in the PFC of alcoholics and binge drinkers.

Ways to Reduce Binge Drinking among College Students
Model for reducing binge drinking in college students has been identified by a research team at the American Osteopathic Association. The study finds that women and non-white students are more receptive to responsible drinking or abstinence.

"These findings may help explain why human adolescent binge drinkers have memory problems,," Salling says, "but they also suggest that there are ways to intervene."

Harrison and Salling found that binge drinking altered neuron excitability by interfering with channels that allow ions to flow into the neurons.

"Targeting these channels may restore normal patterns of activity in the PFC and improve working memory," says Harrison, who adds that neurobiological studies such as this are needed to develop new treatments for alcohol use disorders.

"Most adults with alcohol use disorders begin their excessive drinking as teenagers. If we hope to find ways to prevent or treat these disorders, it's critical that we understand not only the social and environmental factors that contribute to early binge drinking but also the changes that occur in the brain that lead to alcohol addiction."

Source-Eurekalert