Kindlin-3, a protein believed to be limited to the hematopoietic system, has been identified as a major player in both the formation and spread of breast cancer to other organs.
A Transcription Factor Called SLUG Helps Determine Type of Breast Cancer
New research suggests that during breast-tissue development, a transcription factor called SLUG plays a role in regulating stem cell function.
New research suggests that during breast-tissue development, a transcription factor called SLUG plays a role in regulating stem cell function.
To make this discovery, Pluskota and colleagues searched gene expression databases to identify gene products that are elevated in breast cancer, and therefore, likely candidates to be involved in the disease progression. They found that Kindlin-3 expression levels are significantly elevated in breast cancer tumors when compared to the adjacent normal mammary tissue. In fact, Kindlin-3 was in the top 3 percent of gene products elevated in breast cancer cells. Then the scientists studied two groups of animal models. The first group (control group) was implanted with cancer cells that did not express Kindlin-3, while the second group (experimental group) received cancer cells that were engineered to express high levels of Kindlin-3. The experimental group developed bigger tumors that grew significantly faster, metastasized more, and were more angiogenic than the control group. Further biochemical analyses showed that Kindlin-3 enhanced the production and secretion of VEGF, a molecule that is required for the formation of new blood vessels. This study also identified a previously unknown function of Kindlin-3; the regulation of epithelial-mesenchymal transition, a process required for cancer cells to become mobile and invasive.
"Just when scientists thought they knew all there was to know about Kindlin-3, we now learn that this protein has mostly been flying under the radar in breast cancer research all along," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This discovery puts us on a path toward developing treatments, which slow, stop or reverse the progression of some of the most aggressive breast cancers."
Type of Breast Cancer Surgery Women Undergo Influenced by Surgeons and Health Care Settings
Physicians may not recommend a specific treatment option for a few major illnesses, and breast cancer is one of them.
Physicians may not recommend a specific treatment option for a few major illnesses, and breast cancer is one of them.
Patient's Employment Affected After Receiving Chemotherapy Following a Breast Cancer Diagnosis
The loss of paid employment after a diagnosis of early-stage breast cancer may be common and potentially related to the type of treatment patients received, reports a new study.
The loss of paid employment after a diagnosis of early-stage breast cancer may be common and potentially related to the type of treatment patients received, reports a new study.
After Breast Cancer Treatment, Unemployment is Common
Nearly one-third of breast cancer survivors who were employed before treatment, were jobless four years later.
Nearly one-third of breast cancer survivors who were employed before treatment, were jobless four years later.
