Heart disease is the leading cause of death for both men and women and one of the top reasons for this, is that heart muscle is one of the least renewable tissues of the body.
Heart Attack - Overview
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary occlusion.
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary occlusion.
‘Dystroglycan 1, a component of the DGC pathway, directly binds to Yap, a part of the Hippo pathway, and this interaction inhibits cardiomyocyte proliferation.
’
"We are investigating the question of why the heart muscle doesn't renew. in this study, we focused on two pathways of cardiomyocytes or heart cells; the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for cardiomyocyte normal functions," shared senior author Dr. James Martin, professor and Vivian L.Smith Chair in Reenegrative Medicine at Baylor College of Medicine. Previous work had hinted that components of the DGC pathway may somehow interact with members of the Hippo pathway. In this research, Martin and colleagues studied the consequences of this interaction in animal models. The researchers genetically engineered mice to lack genes involved in one or both pathways, and then determined the ability of the heart to repair an injury.
Martin shared, "The discovery that the Hippo and the DGC pathways connect in the cardiomyocyte and that together they act as 'brakes' or stop signals to cell proliferation opens the possibility that by disrupting this interaction one day it might be possible to help adult cardiomyocytes proliferate and heal injuries caused by a heart attack, for example.
Broken Heart Syndrome | Takotsubo Syndrome (TTS) - Causes, Symptoms, Diagnosis & Treatment
Broken heart syndrome is short-term failure of the heart muscles caused by stress, war, or surgery. Balloon-shaped ventricle is a characteristic symptom.
Broken heart syndrome is short-term failure of the heart muscles caused by stress, war, or surgery. Balloon-shaped ventricle is a characteristic symptom.
Advertisement
Lifestyle Paths to Prevent Heart Disease
Heart disease can be of many types depending upon whether they involve the heart muscles or artery walls or heart beats. Bad lifestyle choices contribute to heart disease.
Heart disease can be of many types depending upon whether they involve the heart muscles or artery walls or heart beats. Bad lifestyle choices contribute to heart disease.
Congenital Heart Defects - Causes, Symptoms, Diagnosis & Treatment
Congenital heart defects are structural abnormalities of the heart present at birth, and that affect blood flow through the heart and to the rest of the body.
Congenital heart defects are structural abnormalities of the heart present at birth, and that affect blood flow through the heart and to the rest of the body.
