Lecanemab's Surge: Alzheimer's Breakthrough Amid Gender Concerns

Since receiving approval from the U.S. Food and Drug Administration in 2023 as only the second Alzheimer’s-modifying drug, sales of lecanemab, marketed as Leqembi, have consistently increased, hitting $87 million USD in the final quarter of 2024 (1^✔ ✔Trusted Source
The higher benefit of lecanemab in males compared to females in CLARITY AD is probably due to a real sex effect

Go to source). In its Phase 3 clinical trial, lecanemab slowed cognitive decline by 27 percent overall, yet one subset of data suggested little to no benefit in females, though the cause of the difference was not clear. An FDA committee voted unanimously that the Phrase 3 trial verified the clinical benefit of lecanemab. Even so, several follow-up papers focused on the trial’s apparent sex difference result to cast doubt on prescribing lecanemab to females.

Findings on Lecanemab's Effectiveness in Males vs. Females

To test whether the lecanemab trial truly showed a sex difference in drug effectiveness, McGill Ph.D. candidate Daniel Andrews, in collaboration with researchers led by neuroscientist Prof. Louis Collins, ran simulated trials on openly available Alzheimer’s patient data, using the same demographics and constraints as the lecanemab trial. They found that indeed lecanemab was probably less effective in females than males in the Phase 3 trial. However, there was insufficient evidence to say the drug was totally ineffective in females.

In some patients, lecanemab causes serious side effects. Andrews’ and Collins’ findings should better prepare clinicians to decide whether the potential benefits of lecanemab outweigh the potential harms in female patients, and may inform future consideration of the drug’s approval in other countries. The findings also suggest ways future drug trials can better account for sex differences.

Their results were published in The Journal of the Alzheimer's Association.

Reference:

1. The higher benefit of lecanemab in males compared to females in CLARITY AD is probably due to a real sex effect - (https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14467)

Source-Eurekalert