Acute myeloid leukemia (AML) is a blood cancer that occurs in the bone marrow and the soft inner parts of bones. A new study explored the link between down syndrome and this cancer from a hematologic and genetic perspective.
Acute Myeloid Leukemia-Causes-Symptoms-Diagnosis-Treatment-Prognosis-FAQs
Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike
Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike
‘CD117/KIT is a unique protein present in disease-driving stem cells. Several small molecular inhibitors against this protein demonstrated significant efficiency in eliminating the preleukemic stem cells.’
"For the first time, our model is giving us insight into the human leukemia process. Ultimately, we may be able to prevent the acute illness by treating it in its earliest phase, when it is preleukemic, to prevent its progression to full-blown leukemia," said Dr. John Dick, Senior Scientist from the laboratory of Princess Margaret. The team used human down syndrome cells acquired from a tissue biobank and an advanced CRISPR/Cas9 approach in their study. During the analysis, they detected preleukemia-specific cellular and genetic events. Notably, the team found that as early as the second trimester of a fetus with down syndrome, preleukemia originates from the long-term hematopoietic cells with a peculiar kind of mutation called GATA1 mutation.
The transition from preleukemia to acute leukemia occurs only if the extra copy of chromosome 21 and the GATA1 mutation are in place. "We actually created a human disease in a preclinical model by showing how the genetically edited, as well as the normal human blood stem cells, behave in it, and we succeeded in recreating the precise, progressive steps of how leukemia develops," says Dr. Dick.
New Molecule Kills Resistant Cancer Cells in Acute Myeloid Leukemia
Scientists have discovered the first compound which kills resistant cancer cells in acute myeloid leukemia but spares healthy cells.
Scientists have discovered the first compound which kills resistant cancer cells in acute myeloid leukemia but spares healthy cells.
The researchers highlighted how their findings could be expanded to other childhood cancers and transform the pediatric cancer field.
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Down Syndrome - Trisomy 21, Causes, Symptoms, Diagnosis, Treatment, Prognosis
Down Syndrome is a congenital disorder among children commonly born to older mothers. The condition is also known as ‘Up syndrome’ because of the cheerful persona of the Down children.
Down Syndrome is a congenital disorder among children commonly born to older mothers. The condition is also known as ‘Up syndrome’ because of the cheerful persona of the Down children.
Source-Medindia
Test your Knowledge on Down Syndrome
Down syndrome also known as Trisomy 21 is a genetic disorder caused by the presence of a third copy of chromosome 21. Down syndrome leads to impairments in cognitive ability and physical growth of the child.
Down syndrome also known as Trisomy 21 is a genetic disorder caused by the presence of a third copy of chromosome 21. Down syndrome leads to impairments in cognitive ability and physical growth of the child.
