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Link Between Kidney Damage from COVID-19 and Higher In-hospital Death Risk

by Colleen Fleiss on Sep 23 2020 3:28 AM

A new study has evaluated the incidence, risk factors, and prognosis of acute kidney injury in adults with COVID-19.

Link Between Kidney Damage from COVID-19 and Higher In-hospital Death Risk
Many individuals who develop coronavirus were found to experience kidney damage or acute kidney injury (AKI), stated findings that appear in an upcoming issue of CJASN.
The study was conducted on 1,392 patients who tested COVID-19 positive //by investigators led by Gang Xu, PhD, and Shuwang Ge, MD. The study was conducted in Tongji hospital in Wuhan, China.

Study Findings
  • 7% of COVID-19 patients developed AKI during hospitalization, many within seven days after admission.
  • 10% in-hospital mortality rate was observed in patients without AKI vs.72% in patients with AKI.
  • AKI linked to a 5-times higher odds of dying while in the hospital.
  • Death risk is higher with greater severity of AKI.
Factors linked to a higher risk of acute kidney injury include:
  • Severe COVID-19 disease
  • High blood levels of creatinine
  • Low blood levels of certain immune cells
  • Increased blood levels of a protein fragment indicative of elevated blood clot formation.
Acute Kidney Injury
  • Every year, there are around 13.3 million cases of AKI.
  • Out of 1.7 million global deaths per year caused by AKI, around 1.4 million occur in low- and middle-income countries.
"Prior to this study, there was limited information concerning epidemiological characteristics and outcomes associated with AKI in patients with COVID-19," said Dr. Xu. "Our results indicate that AKI is strongly associated with mortality, and that careful monitoring of AKI is necessary early in the course of infection."

Source-Medindia


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