![Liver Transplants Superior for Metastatic Colorectal Cancer Liver Transplants Superior for Metastatic Colorectal Cancer](https://images.medindia.net/health-images/1200_1000/Liver-Transplantation.jpg)
Progression-Free Survival for Liver Transplant vs Alternative Therapy in Unresectable Colorectal Liver Metastasis
Go to source) In the study, published in JAMA Surgery, patients who had liver transplants tended to live longer without cancer progression than patients who opted for other treatments. While previous studies have shown the benefits of liver transplant for these patients, this is the first study to compare liver transplant to other treatment options.
‘#Livertransplants could be a game-changer for certain patients with advanced #colorectalcancer. #transplantation’
![pinterest](https://images.medindia.net/icons/news/social/pinterest.png)
“In any cancer treatment, it's very easy to describe the outcomes of the patients who received the intervention, but similar patients that did not undergo the intervention can serve as a good comparison,” said Matthew Byrne, MD, a surgery resident at URMC and author of the study. “Without randomized, controlled trial data, this study offers the best evidence that is available to understand whether liver transplant provides better outcomes over other treatments.” ![twitter](https://images.medindia.net/icons/news/social/twitter.png)
![facebook](https://images.medindia.net/icons/news/social/facebook.png)
![whatsapp](https://images.medindia.net/icons/news/social/whatsapp.png)
![linkedin](https://images.medindia.net/icons/news/social/linkedin.png)
![pinterest](https://images.medindia.net/icons/news/social/pinterest.png)
Liver Transplants Extend Survival and Delay Cancer Progression
The study, led by Roberto Hernandez-Alejandro, MD, chief of Abdominal Transplant and Liver Surgery at URMC, followed 33 patients whose colorectal cancer was under control, but who had liver tumors that could not be surgically removed. All 33 patients were eligible for liver transplantation, but only 20 chose to have a transplant, while 13 opted for other classical therapies, like removal of part of the liver, chemotherapy, or liver-directed therapies.Compared to the classical therapy group, the liver transplant group had significantly higher progression-free survival rates across three years of follow up. One year after liver transplant, 90 percent of patients showed no signs of cancer progression. That number dropped to 73 percent after two years and to 36 percent at three years. On the other hand, only 42 percent of patients who opted for other therapies were cancer-progression-free after one year, which dropped to roughly 10 percent after two and three years.
The transplant group also had higher overall survival rates than the standard therapy group, though the difference wasn’t statistically significant. At the three-year follow up, 90 percent of transplant patients had survived, compared to 73 percent of patients who received other therapies.
Though this study provides solid evidence, larger clinical trials will be needed to fully understand the added benefit of liver transplant compared to other treatments for these patients—and to better refine which patients benefit most.
Advertisement
Because livers from deceased donors are in short supply, 17 of the 20 liver transplant patients in the study received liver tissue from living donors.
Advertisement
“Right now, URMC is the largest center in the country and the second largest center in the world, doing liver transplant for colorectal liver metastases,” said Hernandez-Alejandro, who led the recent effort to establish a living-donor liver transplant program at URMC.
Reference:
- Progression-Free Survival for Liver Transplant vs Alternative Therapy in Unresectable Colorectal Liver Metastasis - (https://jamanetwork.com/journals/jamasurgery/article-abstract/2821589)