Duration of a woman’s fertility period can be a risk factor for dementia. Women with more extended fertility periods are associated with an increased risk of dementia after the age of 85.
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‘Longer reproductive period increases a woman’s risk of developing dementia after 85 years. Estrogen also plays a role in dementia risk in women.’
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The study consisted of 1,364 women who were followed between 1968 and 2012 in the studies ‘Prospective Population-based Study of Women in Gothenburg’ (PPSW) and the ‘Gothenburg H70 Birth Cohort Studies in Sweden’ (the H70 studies).Read More..
The ‘reproduction period’ of a woman consists of the years between the onset of menstruation (menarche) and when the menstruation ceases (menopause).
In the study, 16% (53 of 333 individuals) of the women with a shorter reproductive period of 32.6 years or less developed dementia.
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The difference between the risk of dementia in the two fertility periods was 8%. The study also shows that dementia risk increases with every additional year the woman remains fertile.
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Several studies have focused on the effects of estrogen in the form of hormonal therapy on the risk of dementia. However, few studies show that the risk of dementia is reduced and few others show it increases, especially in women who take estrogen late in life.
In the current study, the researchers investigated the effects of endogenous estrogen on the risk of dementia.
The researchers were able to collect information on several events in the woman’s life that can affect levels. Thus, the results are more reliable.
"The varying results for estrogen may be due to it having a protective effect early in life but being potentially harmful once the disease has begun," said the researchers.
The duration of women's fertile periods is one risk factor for dementia among many.
Most women with delayed menopause do not develop dementia because of this factor alone. However, most people are affected by the age of 80.
The study explains why women have a higher risk of developing dementia and Alzheimer's disease than men after age 85 and provide further support for the hypothesis that estrogen affects the risk of dementia among women.
Source-Medindia
