Low Blood Oxygenation Associated With Impaired Kidney Function and Diabetic Nephropathy

Hypoxemia also called as low oxygen desaturation is defined as an abnormally-low partial pressure of oxygen in the arterial blood.

Examining the poorly understood link between obstructive sleep apnea (OSA) and type 2 diabetes complications, researchers identified specific measures of low blood oxygenation that are associated with impaired kidney function and diabetic nephropathy.

The study by Linong Ji, and colleagues, Peking University People's Hospital and Peking University Health Science Center (Beijing, China), is published in Diabetes Technology & Therapeutics (DTT).

Link Between Obstructive Sleep Apnea and Diabetic Peripheral Neuropathy
In patients with type 2 diabetes, strong association exists between obstructive sleep apnea and diabetic peripheral neuropathy.

‘Nocturnal hypoxemia caused by obstructive sleep apnea is associated with diabetic nephropathy and renal function of patients with type 2 diabetes.’

In the article "Association of Diabetic Microvascular Complications and Parameters of Obstructive Sleep Apnea in Patients with Type 2 Diabetes", the researchers describe the use of overnight sleep monitoring with measurement of respiratory parameters including the apnea hyponea index, oxygen desaturation index, oxygen saturation, and the total time oxygen saturation was below 90% or 85%. They report which parameters of nocturnal hypoxemia were more closely linked to diabetic microvascular complications such as renal disease.

"Adequate sleep has been a topic of discussion recently, and this study highlights the association of sleep apnea with microvascular disease associated with diabetes," says DTT Editor-in-Chief Satish Garg, Professor of Medicine and Pediatrics at the University of Colorado Denver. "To some extent this finding may be associated with obesity, which is a common occurrence with type 2 diabetes."

Obstructive Sleep Apnea and Daytime Sleepiness Among Men Linked to Depression
Men who had been previously undiagnosed and also suffered from excessive daytime sleepiness had 4 to 5 times greater chances of having depression.

Source-Eurekalert

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