A new treatment approach based on nanotechnology was found effective for the most common type of lung cancer, non-small cell lung cancer (NSCLC) in mouse models.
Lung Cancer - Types, Causes, Symptoms, Diagnosis, Treatment and Prevention
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
‘Non-small cell lung cancer (NSCLC), a common type of lung cancer is difficult to treat. A new treatment approach based on nanotechnology was found effective in mouse models. More tests are needed before the technology is ready to be tested in human clinical trials.’
To bypass these limitations, Sunday Shoyele, PhD, Associate Professor in the Department of Pharmaceutical Sciences at Jefferson (Philadelphia University + Thomas Jefferson University) and colleagues, developed a nanoparticle comprised of four parts. First, Dr. Shoyele included part of a human antibody, immunoglobulin G (IgG), to cloak the particle from the immune system. Second, the research team added the MUC1 antigen, which acts like a navigation system guiding the nanoparticles to the MUC1-covered lung tumors. Finally, the therapeutic payload, microRNA-29b, along with the other two components are glued together using a sticky polymer called poloxamer-188. Dr. Shoyele and colleagues showed that these components formed a spherical nanoparticle capable of properly finding the lung tumors and shrinking the tumors in mouse models of the disease. "This work extends our previous work demonstrating that these particles were effective in shrinking tumor tissue in a petri dish. Here we show that they are also effective in a more complex living system," said Dr. Shoyele.
Additional tests are needed before the technology is ready for testing in human clinical trials. Dr. Shoyele plans to continue the research with comprehensive toxicity tests and scaling the nanoparticle manufacturing process for clinical trials.
Combination Targeted Therapies may Improve Outcomes in Advanced Non-Small Cell Lung Cancer (NSCLC)
Non-small cell lung cancers show genetic changes during treatment with targeted therapy; combination targeted therapies or regular monitoring of genetic changes during treatment may be required.
Non-small cell lung cancers show genetic changes during treatment with targeted therapy; combination targeted therapies or regular monitoring of genetic changes during treatment may be required.
Source-Eurekalert
Novel Blood Test Allows Quicker, Precise Therapy of Non-Small Cell Lung Cancer
Novel blood test that detects specific mutations in non-small cell lung cancer (NSCLC) may help initiate accurate therapy early and improve patient outcome.
Novel blood test that detects specific mutations in non-small cell lung cancer (NSCLC) may help initiate accurate therapy early and improve patient outcome.
Encouraging Results for New Antibody Drug in Non-Small Cell Lung Cancer Patients
From a trial of an antibody that helps the immune system to recognise and attack cancer cells, new results have shown particularly encouraging responses in patients who are smokers or former smokers.
From a trial of an antibody that helps the immune system to recognise and attack cancer cells, new results have shown particularly encouraging responses in patients who are smokers or former smokers.
