Male Infertility: Fresh Insights

A novel genetic mechanism that can cause severe forms of male infertility has been discovered by researchers. Experts identified mutations in the gene RBM5 in multiple infertile men.

A novel genetic mechanism that can cause severe forms of male infertility has been discovered by Newcastle University scientists.

This breakthrough in understanding the underlying cause of male infertility offers hope of better treatment options for patients in the future.

About Male Infertility
Encyclopedia section of medindia briefs you about the Genetics of Male Infertility

‘Experts identified mutations in the gene RBM5 in multiple infertile men.’

The study, published today in Nature Communications, shows that new mutations, not inherited from father or mother, play a major role in this medical condition.

Experts have found that mutations occurring during the reproduction process, when the DNA of both parents is replicated, can result in infertility in men later in life.

Improving understanding

New Genetic Link to Male Infertility Identified
Genetic variation of Y chromosome in patients with spermatogenic impairment has been studied for the first time and researchers concluded saying there is a link between the Y chromosome and male infertility.

It is hoped that this new knowledge will help to provide more answers in the future about the cause and best treatment options available to infertile couples.

Professor Joris Veltman, Dean of Newcastle University’s Biosciences Institute, UK, led the research which involved patients from Newcastle Fertility Centre and Radboud University Medical Centre in the Netherlands.

Causes Of Female Infertility Revealed
Few genes play a far more complex role in oocyte maturation than previously assumed according to geneticists.

He said: “This is a real paradigm shift in our understanding of the causes of male infertility. Most genetic studies look at recessively inherited causes of infertility, whereby both parents are a carrier of a mutation in a gene, and the infertility occurs when the son receives both mutated copies, resulting in problems with their fertility.

“However, our research has found that mutations which occur when the DNA is replicated during reproduction in parents plays a significant role in the infertility in their sons.

New Target for Treating Male Infertility Identified
The protein, SKP1, drives a key transition step in male meiosis, the type of cell division process that results in sperm, School of Veterinary Medicine researchers found.

“At present, we don’t understand the underlying cause in the majority of infertile men, and this research will hopefully increase the percentage of men for whom we can provide answers.”

Scientists collected and studied DNA from a global cohort of 185 infertile men and their parents. They identified 145 rare protein-altering mutations that are likely to negatively impact male fertility.

As many as 29 of the mutations affect genes directly involved in processes related to spermatogenesis – the process of sperm cell development - or other cellular processes related to reproduction.

Previous research carried out in mice has shown that this gene plays a role in male infertility.

Importantly, these mutations mostly cause a dominant form of infertility, where only one mutated gene is required. As a consequence, there is a 50% chance that infertility caused by these mutations will be passed on to the man’s child (if assisted reproductive technologies are used) and this may result in infertility, particularly in sons.

Millions of children have already been born through assisted reproductive approaches as a result of infertility. This research indicates a significant proportion of these children may inherit infertility from their father.

Professor Veltman said: “If we are able to obtain a genetic diagnosis, then we can start understanding better male infertility problems and why some infertile men still produce sperm that can be used successfully for assisted reproduction.

“With our information, and the research others are doing, we hope clinicians can improve counselling for couples and recommend what is the best course of action in order to conceive, either by proposing an appropriate medically-assisted procedure or in cases where none is suitable, provide appropriate alternatives.”

Infertility problems

It is estimated that up to 7% of men are affected by infertility and 50% of fertility problems within a heterosexual couple are due to the man. In around half of male infertility cases, the cause is unexplained.

Moving forwards, the scientists want to expand their work by studying thousands of patients and their parents in a large international consortium.

They will follow-up their research by conducting further studies into the role these newly identified mutated genes have on the impact of spermatogenesis and on the overall fertility in humans.

Reference: A de novo paradigm for male infertility. Oud MS et al. Nature Communications. Doi 10.1038/s41467-021-27132-8

Source-Eurekalert