Mental Health Toll of Rare Cancers

Patients with rare cancers are at a significantly higher risk of developing anxiety and depression compared to those with common cancers, underscoring the need to address mental health in this group, as per a study published in eClinicalMedicine ().

The systematic review and meta-analysis of these patient cases, led by Assistant Professor Valerie Yang, Consultant Medical Oncologist at the National Cancer Centre Singapore (NCCS) and Joint Research Clinician and Group Leader at the A*STAR Institute of Molecular and Cell Biology (IMCB) indicate that patients with rare cancers are significantly more likely to develop anxiety and depression, and have higher incidence of suicides and post-traumatic stress disorder (PTSD).

Ease Anxiety & Depression: Resistance Training's Surprising Benefits
Explore the positive impacts of resistance exercise training on alleviating symptoms of anxiety and depression.

‘Did You Know?
Addressing mental health in cancer care can improve treatment outcomes by up to 20%, highlighting the importance of holistic patient support. #cancer #mentalhealth’

Rare cancers, defined as those affecting fewer than 6 out of 100,000 people per year, often pose unique diagnosis, treatment, and research challenges.

Because there is a low incidence of each type of rare cancer, there is often a lack of awareness among the public and medical professionals of these diseases, leading to delayed diagnoses and limited treatment options.

The Overlooked Mental Health Crisis

Due to the lack of support and resources tailored to their specific condition, patients with rare cancers may experience isolation which can negatively impact their mental health.

Does Excessive Cannabis Use Increase Anxiety Disorder Risk?
Individuals with a history of cannabis-related ED visits, faced an increased risk of developing new anxiety disorders compared to the general population.

Although there have been numerous studies looking at the psychological outcomes of patients with common cancers, this was the first study to systematically examine the psychological impact of suffering from a rare cancer compared to a common cancer.

As there are fewer individuals with rare cancers, clinicians may also be less attuned to the psychological challenges faced by these patients.

India's Rural Mental Health Program Shows Promise
Digital health solutions could greatly enhance India’s National Mental Health Program, aligning with WHO and Lancet recommendations for tackling mental disorders globally.

This study showed that rare cancer patients are nearly three times more likely to develop anxiety and depression as compared to patients with common cancers.

This group also has a high incidence of suicide (over 300 per 100,000 people) and post-traumatic stress disorder (18%).

Unlocking the Macrophage's Secret Weapon Against Cancer
An appetizer can stimulate immune cells' appetite, offering a potential boost for cancer treatments by enhancing macrophages' ability to target cancer cells.

Importantly, the authors identified specific risk factors in patients with rare cancers who may develop these negative psychological outcomes. This includes having advanced disease, chemotherapy treatment, lower income, and social status.

“The prevalence of poor mental health in patients with rare cancers highlights the need for early identification and intervention. Increased awareness among healthcare professionals is crucial to help identify patients with psychological concerns and monitor patients’ mental well-being during the course of their treatment. While each individual diagnosis might be rare, as a whole, rare cancers actually account for 25% of all cancers. This, coupled with the rising burden of rare cancers globally, highlights the critical need for more support for this group of patients,” said Dr Yang.

The Silent Struggle of the Cancer Patients

Mr Soh Kim Hai, a patient of Dr Yang’s who was diagnosed with Stage IV Soft Tissue Sarcoma in July 2022, is a patient who struggled to cope with the disease.

After diagnosis, he lost his job and a place to live which was provided by his workplace. The resulting fear and uncertainty severely impacted his mental health.

He was supported by medical social workers at NCCS for help and got emotional support. During the sessions, he shared his stress about his living conditions and was assisted to find a new place to live.

After the move, on the suggestion of his brother, he took up painting, which provided a much-needed cathartic outlet for his emotions and helped his mental wellbeing.

Despite the current lack of treatments for patients with rare cancers, novel approaches in translational research and personalized medicine are gradually improving outcomes for rare cancer patients, offering hope for more effective treatments and better quality of life.

Dr Yang also leads the Translational Precision Oncology Laboratory at IMCB, in close clinical collaboration with NCCS and Singapore General Hospital (SGH), as well as scientific collaborations with the National University of Singapore (NUS) and A*STAR’s Bioinformatics Institute (BII) and Singapore Immunology Network (SIgN).

The collaborative team has built a translational research program to find better ways to treat these patients.

The research team is now working closely with the clinical team to develop strategies, such as early identification of patients for referral to medical social workers, to better support patients with rare cancers.

These strategies, if proven successful, can then be applied to manage the psychological needs of all vulnerable patient populations.

Reference:

Psychological outcomes in patients with rare cancers: a systematic review and meta-analysis - (https://www.sciencedirect.com/science/article/pii/S2589537024002104?via%3Dihub)

Source-Eurekalert