Merck's Keytruda Improves Overall Survival In Lung Cancer Study

Lung cancer patients who were given 2mg of Keytruda had longer overall survival compared with those taking docetaxel, a standard treatment for lung cancer.

The US drugmaker Merck & Co's approved Keytruda lung cancer treatment showed promising results in a late-stage study of patients with advanced lung cancer by providing superior overall survival to chemotherapy. Tumors of patients of advanced disease produced a protein called PD-L1 associated with increased risk of the disease.

The U.S. drug maker released a statement saying that its Keynote-010 study, a randomized Phase two-third trial, showed that patients who were taking two different doses of Keytruda (FDA-approved two mg/kg dose and treatment dose of 10 mg/kg given every three weeks) had longer survival compared to those who took docetaxel, the drug widely used for non-small cell lung cancer (NSCLC). The results show that the success of the trial made the researchers meet their primary objective.

For Treating Advanced Melanoma, New Cancer Drug Shows Promise
Researchers report that a new drug in preliminary tests has shown promising results with very manageable side effects for treating patients with melanoma, the deadliest form of skin cancer.

‘The drug Keytruda is used for treatment of Lung Cancer and acts by enabling the patient''s own immune system to recognize and therefore attack the cancer.’

Researchers say that patients whose tumors have high levels of PD-L1, a protein linked to increased risk of the disease, had longer survival to chemotherapy without progression of the disease. This drug will be used for patients with metastatic or advanced lung cancer who did not respond to previous treatments.

Safety of Keytruda was consistent with what had been seen in previous trials among lung cancer patients, Merck said in a release that included only summary "topline" information from the results.

More detailed data from the study will be provided soon, Merck said, adding that it will ask the U.S. Food and Drug Administration later this year to add the new data to the drug's package insert label.

Keep the 'New' Cancer Drug in Your Medicine Cabinet
It turns out that the same types of drugs that help reduce runny noses and watery eyes during allergy season might also help ward off tumors.

Upon approval of this drug earlier this month, the trial showed that it shrank the tumor cells of patients who possess faulty PD-L1 by 41 percent with effects lasting for up to nine months. "Our growing understanding of underlying molecular pathways and how our immune system interacts with cancer is leading to important advances in medicine," FDA spokesperson Dr. Richard Pazdur said when they approved the drug.

"Today's approval of Keytruda gives physicians the ability to target specific patients who may be most likely to benefit from this drug," he added.

Target of Anticancer Drugs Have Broader Functions
Histone deacetylases (HDACs) are the drugs that inhibit the activity of enzymes. They are being widely developed for treating cancer and other diseases, with two already on the market.

Wall Street analysts expect cancer immunotherapies to earn combined annual sales of over $20 billion by 2020.

Source-Medindia

In Treating Wet AMD, Cheaper Anti-cancer Drug Equally Effective as Expensive Drug
In treating the most common cause of blindness in older adults, an anti-cancer drug has been proven to be equally as effective and as a more expensive drug specifically formulated for this purpose.