Scientists have found far more disturbances in metabolic pathways in type 2 diabetes. There was also a correlation between the alterations and the different stages diabetes.
Metabolic Alterations in Type 2 Diabetes
“We detected many protein levels that were either higher or lower than normal in tissues from people at different stages of disease. People with prediabetes displayed major alterations that are associated with inflammation, coagulation and the immune system in the pancreatic islets. In fully developed type 2 diabetes there were more widespread abnormalities, for example in lipid and glucose metabolism and in energy production in the liver, muscle and fat,” says Professor Claes Wadelius, who coordinated the study. The study builds on tissue samples collected from donors at different stages of disease and healthy individuals. The samples have been collected in the strategic initiative EXODIAB, which is led in Uppsala by Professor Olle Korsgren.
Type 2 Diabetes - Risk Factors - Symptoms & Signs - Management - Prevention
Globalization and changing lifestyles has made diabetes very common in developing countries so much so that India is known as the Diabetes Capital of the World.
Globalization and changing lifestyles has made diabetes very common in developing countries so much so that India is known as the Diabetes Capital of the World.
‘The most typical alterations in people with type 2 diabetes are insufficient secretion of insulin and reduced sensitivity to insulin in different organs.’
Using novel techniques, the researchers could quantify thousands of proteins from each organ and therefore obtain a view of the metabolism that has not been possible before. “The techniques for measuring proteins have evolved rapidly in recent years and our colleagues at Copenhagen University who participated in the study are world leaders in the field,” says Dr Klev Diamanti, who performed the analyses in Uppsala together with Associate Professor Marco Cavalli and Professor Jan Eriksson.
In summary, the findings show a highly disturbed metabolism in different pathways in examined organs and at different stages of disease. The data points to new potentially causal mechanisms of the disease, which can be further investigated in the search for new ways of preventing or treating type 2 diabetes.
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the demand for medication by 20% and helps you stay healthy.
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the demand for medication by 20% and helps you stay healthy.
Source-Eurekalert
Diabetes Risk Assessment Calculator
Almost one-third of the people are unaware of the risk factors of diabetes. Find out if you run the risk of diabetes by using Diabetes Risk Assessment calculator.
Almost one-third of the people are unaware of the risk factors of diabetes. Find out if you run the risk of diabetes by using Diabetes Risk Assessment calculator.
Quiz on Low-Calorie Diet for Diabetes
Dietary approach in managing type 2 diabetes has been shed light by researchers for several years. Calorie-reduced diet has been popularly studied to know its benefits and cons in diabetes. Take up this quiz to evaluate yourself and refresh your knowledge on low calorie diet for diabetes.
Dietary approach in managing type 2 diabetes has been shed light by researchers for several years. Calorie-reduced diet has been popularly studied to know its benefits and cons in diabetes. Take up this quiz to evaluate yourself and refresh your knowledge on low calorie diet for diabetes.
