Researchers have identified a specialized and distinctive type of microglia with enhanced antioxidant function in stroke mice.
Role of Microglia in Causing Stroke
Microglia, the primary immune cells in the central nervous system (CNS), are known to eliminate unwanted germs and debris and remove dying neurons. In this study, the research team classified a new type of microglia with enhanced antioxidant function and markers similar to those of disease-associated microglia (DAM), designated them as stroke-associated microglia (SAM).
How to Deal with a Stroke - Signs - Symptoms - Risk Factors - Prevention
Stroke is a brain attack, which occurs when the blood supply to the brain is interrupted. It affects all age groups; according to the WHO, 15 million people are affected by stroke annually.
Stroke is a brain attack, which occurs when the blood supply to the brain is interrupted. It affects all age groups; according to the WHO, 15 million people are affected by stroke annually.
‘Prdx1-dependent SAM may be a potential biomarker and therapeutic target for protecting microglial function and treating brain I/R injury.’
Through animal experiments, the research team demonstrated that the presence of the typical antioxidant gene, Peroxiredoxin-1 (Prdx1), protects against acute I/R injury and is required for SAM activation and the consequent reduction of microglial cell death and inflammatory responses. In addition, after performing transient middle cerebral artery occlusion (tMCAO) surgery to induce ischemic stroke in mice, the research team found that Prdx1−/− mice were more severely injured by acute I/R injury, as confirmed by TTC staining, neurological deficit scores, motor tests, and the survival rate, indicating that Prdx1 has a protective function.
He adds, “Although this new cluster will require further study, our findings provide a new perspective that Prdx1-mediated microglial heterogeneity is important in ischemic stroke.”
Stroke Risk Calculator
Stroke Risk Calculator checks if you have hypertension, diabetes and heart failure and predicts the risk of stroke (cerebrovascular accident) in next 10 years.
Stroke Risk Calculator checks if you have hypertension, diabetes and heart failure and predicts the risk of stroke (cerebrovascular accident) in next 10 years.
Their findings have been published in the August 2022 issue of Redox Biology, a renowned journal in the areas of both health and disease. This study was carried out with the support of the National Research Foundation of Korea (NRF).
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Quiz on Stroke
Stroke is the third leading cause of death world over. Besides, it also disables the affected people, making them completely dependent on caregivers for their daily needs. Lifestyle greatly affects the chances of developing a stroke. Thus, the incidence of stroke can be brought down to a great extent by leading a healthy lifestyle. Here is a quiz that tests if you know enough about this disabling condition.
Stroke is the third leading cause of death world over. Besides, it also disables the affected people, making them completely dependent on caregivers for their daily needs. Lifestyle greatly affects the chances of developing a stroke. Thus, the incidence of stroke can be brought down to a great extent by leading a healthy lifestyle. Here is a quiz that tests if you know enough about this disabling condition.
Understanding Brain Death
Interactive section of Medindia helps us in better understanding of Brain Death
Interactive section of Medindia helps us in better understanding of Brain Death
