Explore the latest research on kidney transplant rejection, focusing on microvascular inflammation and its impact on patient outcomes.
The Clinical Significance of Microvascular Inflammation after Kidney Transplantation
Go to source). This type of inflammation is complicated and poses a major challenge in clinical practice. To address this issue, the international Banff classification has updated its guidelines on antibody-mediated rejection diagnostics.
About Transplantation
Since the early times, the novel idea of transplanting tissues and other body parts from one organism to the other has captured the imagination of successive generations.
Since the early times, the novel idea of transplanting tissues and other body parts from one organism to the other has captured the imagination of successive generations.
‘Many #kidneytransplant cases that were thought to be successful had #microvascular_inflammation #medindia’
Microvascular Inflammation in Kidney Transplantation
They have introduced two new categories of microvascular inflammation: mild microvascular inflammation linked to antibody-mediated rejection and microvascular inflammation without antibody-mediated rejection.The new research has found key insights into newly defined rejection entities in kidney transplantation that may offer improved patient risk categorization post-transplant. The research will be presented at ASN Kidney Week 2024 October 23– 27.
In a landmark study analyzing more than 16,000 biopsies from almost 7,000 kidney transplant recipients, researchers found that many cases initially considered as non-rejection were reclassified into the newly defined categories of microvascular inflammation.
Test Your Knowledge on Kidney Transplantation
Kidney transplantation is a surgical procedure done to remove a diseased kidney and replace it with a healthy one from a donor. A person requires one healthy functioning kidney to keep the body functions normal ( ). Once a ...
Kidney transplantation is a surgical procedure done to remove a diseased kidney and replace it with a healthy one from a donor. A person requires one healthy functioning kidney to keep the body functions normal ( ). Once a ...
Risks of Microvascular Inflammation in Kidney Transplants
Importantly, reclassified patients with microvascular inflammation in the absence of antibody-mediated responses displayed an increased risk of graft failure compared with those without signs of rejection, underscoring the importance of this new classification.“Recognizing these phenotypes could improve risk stratification and support more personalized management for kidney transplant patients,” explains first author, Aurélie Sannier, pathologist and researcher at the Paris Institute for Transplantation and Organ Regeneration. “We encourage large studies in other organ transplants where microvascular inflammation is also a critical feature of antibody-mediated rejection.”
Advertisement
Kidney Transplant Recipients Must Get Moving to Save Their Lives
Study says low physical activity increases kidney transplant patients'' likelihood of dying early
Study says low physical activity increases kidney transplant patients'' likelihood of dying early
- The Clinical Significance of Microvascular Inflammation after Kidney Transplantation - (https://www.asn-online.org/about/press/releases/ASN_PR_20241024_Sannier10.17FINAL.pdf)
Source-Eurekalert
Kidney Transplant Patients Provided With New Hope - Use of Normothermic Machine Perfusion With Stem Cells
Normothermic Machine Perfusion (NMP) with adult stem cells increases the function and lifespan of the donor’s kidneys. It opens a new possibility to pre-treat kidneys and increases the number of functional kidneys available.
Normothermic Machine Perfusion (NMP) with adult stem cells increases the function and lifespan of the donor’s kidneys. It opens a new possibility to pre-treat kidneys and increases the number of functional kidneys available.
