A major and unsolved health issue worldwide is disease affecting the kidneys.
![`Mini-Kidney` Structures Generated from Human Stem Cells By Salk Scientists `Mini-Kidney` Structures Generated from Human Stem Cells By Salk Scientists](https://images.medindia.net/health-images/1200_1000/urinary-tract.jpg)
For the first time, the Salk researchers have generated three-dimensional kidney structures from human stem cells, opening new avenues for studying the development and diseases of the kidneys and to the discovery of new drugs that target human kidney cells. The findings were reported November 17 in Nature Cell Biology.
Scientists had created precursors of kidney cells using stem cells as recently as this past summer, but the Salk team was the first to coax human stem cells into forming three-dimensional cellular structures similar to those found in our kidneys.
"Attempts to differentiate human stem cells into renal cells have had limited success," says senior study author Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and holder of the Roger Guillemin Chair. "We have developed a simple and efficient method that allows for the differentiation of human stem cells into well-organized 3D structures of the ureteric bud (UB), which later develops into the collecting duct system."
Source-Eurekalert