Monoclonal Antibody Therapy Induces Macrophages to Target Tumor Cells

Extensive research has shown that monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer.

Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal. In this issue of the Journal of Clinical Investigation, Marjolein van Egmond and colleagues at the VU University Medical Center found that macrophage populations mediate tumor cell removal following monoclonal antibody treatment by actively phagocytosing tumor cells. Macrophage-dependent tumor cell removal required both the high affinity and low affinity Fc receptors. This study suggests that monoclonal antibody therapies that are optimized to enhance macrophage recruitment and activity may enhance removal of circulating tumor cells in cancer patients.

Tumor Markers - For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive results.

Source-Eurekalert

About Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location.

Carcinoid Tumors - Carcinoid Syndrome - Symptoms, Signs, Diagnosis & Treatment
Carcinoid tumors is a benign tumor that results in carcinoid syndrome. Only 8 to 10% of all carcinoid tumors are associated with the carcinoid syndrome.

Pheochromocytoma | Adrenal Gland Tumor: Causes, Symptoms, Diagnosis, Treatment, Prevention
Pheochromocytoma is a rare tumor of the adrenal glands that secretes the catecholamines, adrenaline and noradrenaline. Symptoms, diagnosis, treatment of adrenal gland tumor are explained in detail.