X-linked nephrogenic diabetes insipidus (XNDI) is a severe congenital kidney disease caused by mutations in the V2R gene.
X-linked nephrogenic diabetes insipidus (XNDI) is a severe congenital kidney disease caused by mutations in the V2R gene. Currently, there is no effective drug to specifically treat XNDI, mainly because there are no good animal models of the disease. However, Jürgen Wess and colleagues, at the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, have now developed a viable mouse model of XNDI that recapitulates the major manifestations of the human disease.
As analysis of the mouse model indicated that disease was associated with increased expression in the kidney of the protein EP4, the authors tested selective EP4 receptor agonists as potential therapeutics, and found that they alleviated all the symptoms of disease. The authors therefore suggest that selective EP4 receptor agonists could be of benefit to individuals with XNDI and hope that their mouse model can be used to test additional new therapeutic strategies.
Kidney Stones / Renal Stones - Causes - Symptoms - Diagnosis - Treatment - FAQs
A kidney stone is a solid mass made up of tiny crystals and may appear in any area of the urinary system.
A kidney stone is a solid mass made up of tiny crystals and may appear in any area of the urinary system.
Source-Eurekalert
TAN
Dialysis - Hemodialysis, Peritoneal Dialysis and Role of Diet and Drugs
Dialysis is an artificial process for removing excess water and waste from the blood. Hemodialysis and peritoneal dialysis are the types of dialysis.
Dialysis is an artificial process for removing excess water and waste from the blood. Hemodialysis and peritoneal dialysis are the types of dialysis.
Diet for Kidney Stones
Diet for kidney stone should comprise of calcium-rich foods, increased fluid intake. Other dietary recommendations depends on the type of kidney stone.
Diet for kidney stone should comprise of calcium-rich foods, increased fluid intake. Other dietary recommendations depends on the type of kidney stone.
Acute Renal (Kidney) Failure- Causes, Symptoms, Diagnosis, Treatment and Complications
Acute renal failure is the sudden cessation of the functioning of kidneys, that can be due to reduced renal blood flow, damage to renal tissues.
Acute renal failure is the sudden cessation of the functioning of kidneys, that can be due to reduced renal blood flow, damage to renal tissues.
