The link between skeletal muscle proteome and type 2 diabetes has been evaluated by the team of researchers from the University of Helsinki, the Helsinki University Hospital and the Minerva Foundation Institute for Medical Research.
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‘Physical activity plays a vital role in reducing the risk of developing type 2 diabetes.’
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Mass spectrometry enabled them to identify over 2,000 muscle proteins.Read More..
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The quantity of dozens of proteins had already changed in prediabetic study subjects.
The greatest changes were seen in type 2 diabetes, where the quantity of more than 400 proteins had primarily dropped. Most of these proteins were associated with mitochondrial energy metabolism.
The results highlight the significance of mitochondria when prediabetes is progressing toward type 2 diabetes.
"We found that the levels of mitochondrial muscle proteins are clearly reduced already in prediabetes," Koistinen notes.
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"Still, there already exists an excellent and economical targeted therapy, since regular physical activity increases the number of muscle mitochondria and improves metabolism diversely," Koistinen points out.
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"You can halve the risk of developing diabetes by losing weight, increasing physical activity and observing a healthy diet," Koistinen says.
Source-Medindia