Nano Therapy Protects Micro-preemies' Lungs, Brain

Tiny particles released by mesenchymal stromal cells or MSCs called extra-cellular vesicles effectively prevent bronchopulmonary dysplasia (BPD).

Tiny particles released by mesenchymal stromal cells or MSCs (cells from the umbilical cord) called extra-cellular vesicles effectively prevent bronchopulmonary dysplasia (BPD).

These babies have smaller and weaker lungs that can’t send as much oxygen to their growing brains. The lack of oxygen during brain development can lead to learning disabilities, or problems walking, hearing and seeing.

Bronchopulmonary Dysplasia | Respiratory Insufficiency - Causes, Clinical features, Management
Bronchopulmonary dysplasia or chronic lung disease of infancy is seen in premature and low birth weight infants. It results from lung and airway damage caused by prolonged oxygen therapy and ventilator support in these babies.

‘Very premature babies need extra oxygen and mechanical intervention to breathe, but this damages their lungs, causing a chronic lung disease called bronchopulmonary dysplasia (BPD).’

There is no cure for BPD, but Dr. Bernard Thébaud and his team are hoping to change that. The team previously found that cells from the umbilical cord, called mesenchymal stromal cells or MSCs, could prevent BPD in newborn rats.

Known as MSC-EVs or nanotherapies, these nano-sized particles have similar effects to MSCs but are easier to manufacture, store, and dose. Unlike MSCs, they can cross the blood-brain barrier, meaning they can travel into the brain after being injected into the blood stream. The researchers saw evidence that some MSC-EVs did reach the brain in this study, though most travelled to the lungs.

Not only did MSC-EVs prevent lung injury in this study, they also prevented brain injury. This was the first study to show that BPD impairs some of the key functions of brain stem cells. Brain stem cells can become all the different cells in the brain, and play an important role in brain development.

New Insights into Cleidocranial Dysplasia (CCD), a Rare Disorder
Cleidocranial dysplasia (CCD) is a rare disorder of which the most prominent features are missing or abnormal growth of the teeth and collarbones.

This study comes as Dr. Thébaud and his research team prepare to launch a phase I clinical trial to test the feasibility and safety of using MSCs to treat premature babies with BPD. They hope to evaluate MSC-EVs in future clinical trials.

“A therapy that improves lung and brain health would immensely benefit preterm babies with this chronic lung disease.” -Dr. Bernard Thébaud, neonatologist and senior scientist at The Ottawa Hospital and CHEO and professor at the University of Ottawa.

Thanatophoric Dysplasia Causes Abnormal Development of the Brain
As a gene responsible for Thanatophoric Dysplasia, fibroblast growth factor receptor 3 (FGFR3) has been reported.

Source-Eurekalert

The Lungs
The lungs are our organs of respiration. It is within these, that exchange of gases takes place.