Narcolepsy is an Autoimmune Disease, Says Study

New proof says that narcolepsy, the sleep disorder is an autoimmune disease.

Autoreactive cells have been identified in persons suffering from narcolepsy. This is a new, important proof that the sleep disorder is an autoimmune disease, said University of Copenhagen researchers. This knowledge may lead to better treatment of //the chronic condition, the researchers behind the new discovery believe.

For many years, scientists have expected the sleep disorder narcolepsy of being an autoimmune disease, though without being able to prove it conclusively. Now researchers from the Faculty of Health and Medical Sciences at the University of Copenhagen together with the Technical University of Denmark and Rigshospitalet have found a new, important proof that their presumptions were correct. The new research results have been published in the scientific journal Nature Communications.

Narcolepsy - Overview Incidence Causes Symptoms Diagnosis Treatment Prognosis Prevention FAQs
Sleep is the blissful state that rejuvenates our mind and body everyday and any deprivation often leads to a disorder that can affect our health

‘Autoreactive cytotoxic CD8 T cells found in the blood of narcolepsy patients. ’

'That is, the cells recognise the neurons that produce hypocretin which regulates a person's waking state. It does not prove that they are the ones that killed the neurons, but it is an important step forward. Now we know what the cells are after,' says Associate Professor Birgitte Rahbek Kornum from the Department of Neuroscience.

The immune system is designed to recognise viruses and bacteria. When its cells are autoreactive - which is the case in autoimmune diseases - the immune system recognises the body's own cells and attacks them. That they are cytotoxic means that they are capable of killing other cells. In most narcolepsy patients, the neurons that produce hypocretin and thus regulate our waking state have been destroyed.

'To kill other cells, e.g. neurons producing hypocretin, CD4 and CD8 T cells usually have to work together. In 2018, scientists discovered autoreactive CD4 T cells in narcolepsy patients. This was really the first proof that narcolepsy is in fact an autoimmune disease. Now we have provided more, important proof: that CD8 T cells are autoreactive too,' says Birgitte Rahbek Kornum.

Quiz on Narcolepsy
Narcolepsy is a chronic neurologic disorder that involves loss of brain's ability to regulate sleep and wake cycles normally. People having narcolepsy frequently sleep during the day as compared to those people who don't suffer from it. These sudden attacks of sleep can occur during any type of activity and at any time of the day. A normal sleep pattern involves the early stages of sleep then followed by deeper sleep stages and ultimately rapid eye movement (REM) sleep. In narcoleptic people, REM sleep occurs almost immediately in sleeping cycle and periodically during the waking hours.

Narcolepsy normally starts between ages of 15 and 25, but can become obvious at any age. In many cases, narcolepsy remains undiagnosed and hence untreated.

Autoreactive Cells Were Also Found in Healthy Individuals

Epworth Sleepiness Scale
Measure your daytime sleepiness using this simple interactive tool, based on Epworth Sleepiness disorder Scale. Excessive Daytime Sleepiness is a type of hypersomnia characterized by persistent sleepiness and lack of energy.

In the study, the researchers studied and analysed blood samples from 20 persons with narcolepsy. In addition, they analysed blood samples from a control group of 52 healthy persons. In nearly all 20 narcolepsy patients the researchers found autoreactive CD8 T cells. But autoreactivity was not only found in persons suffering from the sleep disorder. The researchers also discovered autoreactive cells in a lot of the healthy individuals.

'We also found autoreactive cells in some of the healthy individuals, but here the cells probably have not been activated. It is something we see more and more often with autoimmunity - that it lies dormant in all of us, but is not activated in everyone. The next big puzzle is learning what activates them', says Birgitte Rahbek Kornum.

New Hope for Patients With Autoimmune Disease
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According to Birgitte Rahbek Kornum, the discovery of autoreactive cells in healthy individuals also stresses the theory that something has to trigger narcolepsy and activate autoreactivity. Scientists still do not know what causes the disease. They expect a combination of genetics, autoreactive cells and a form of trigger to bring about the disease, e.g. a virus infection. The disease can be treated medically today, but the new research results may pave the way for even better treatments.

'Now there will probably be more focus on trying to treat narcolepsy with drugs allaying the immune system. This has already been attempted, though, because the hypothesis that it is an autoimmune disease has existed for many years. But now that we know that it is T cell-driven, we can begin to target and make immune treatments even more effective and precise,' says Birgitte Rahbek Kornum.

Source-Eurekalert