Nasal brush test is an inexpensive diagnostic test which can accurately identify mild to moderate asthma and differentiate it from other respiratory conditions such as allergic rhinitis, upper respiratory infection, and cystic fibrosis.
Nasal brush test can accurately identify mild to moderate asthma, reports a new study. The findings of the study are published in Scientific Reports. Mount Sinai researchers have identified a genetic biomarker of asthma that can be tested for using a simple nasal brush and basic follow-up data analysis. This inexpensive diagnostic test can accurately identify mild to moderate asthma and differentiate it from other respiratory conditions such as allergic rhinitis, smoking, upper respiratory infection, and cystic fibrosis.
‘Nasal brush test is an inexpensive diagnostic test which can accurately identify mild to moderate asthma and differentiate it from other respiratory conditions such as allergic rhinitis, smoking, upper respiratory infection, and cystic fibrosis.’
The research team, led by a collaboration of clinical and computational scientists in the Department of Genetics and Genomic Sciences, the Icahn Institute for Genomics and Multiscale Biology, and the Department of Pediatrics at the Icahn School of Medicine at Mount Sinai, published their results in Scientific Reports."Mild to moderate asthma can be difficult to diagnose because symptoms change over time and can be complicated by other respiratory conditions," said Dr. Supinda Bunyavanich, physician and researcher at the Icahn School of Medicine. "Our nasal brush test takes seconds to collect -- for time-strapped clinicians, particularly primary care providers at the frontlines of asthma diagnosis, this could greatly improve patient outcomes through early and accurate diagnosis."
Currently, pulmonary function testing (PFT) is the most reliable diagnostic tool for asthma. However, access to the equipment and expertise needed to perform these tests is not always prevalent in primary care settings where asthma is frequently diagnosed and treated. It is also difficult to differentiate between asthma and other respiratory diseases using PFT alone, while the nasal brush and subsequent analysis for this asthma biomarker provides a binary result of asthma or not asthma.
Data scientists leading the study applied machine learning algorithms to the genetic (RNA) data acquired from nasal brushes of patients with and without asthma. This robust data collection, and machine learning analysis identified a 90-gene biomarker indicative of asthma status. "One of the most exciting components of this study is demonstrating the power of machine learning when applied to biomedical data," said Dr. Gaurav Pandey, who led data science efforts to develop the biomarker.
"Collaborations between computational scientists and biomedical researchers and clinicians are advancing medicine at an inspiring pace - we have the power of insights we didn't have many of in the past and that opens a window to an entirely new world of diagnostic tools and treatments"
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Dr. Bunyavanich says the next step to bringing this test into clinical practice is a study in a larger population of patients. "With prospective validation in large cohorts, our asthma biomarker could lead to the development of a minimally invasive test to aid asthma diagnosis at clinical frontlines where time and resources often preclude pulmonary function testing."
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Source-Eurekalert