N-methyl-D-aspartate receptor antagonists and cholinergic inhibitors can alleviate the symptoms of Alzheimer's disease.
![Nasal Mucosal Inhalation of Alzheimer`s Disease Vaccine Attenuates Aβ1-42-induced Cytotoxicity Nasal Mucosal Inhalation of Alzheimer`s Disease Vaccine Attenuates Aβ1-42-induced Cytotoxicity](https://www.medindia.net/afp/images/World-Alzheimers-disease-research-194087.jpg)
Dr. Yunpeng Cao and his team, First Affiliated Hospital of China Medical University, China immunized AD transgenic mouse models with Plp-Adeno-X-CMV-(Aβ3-10)10-CpG via nasal mucosal inhalation. They found that Plp-Adeno-X-CMV-(Aβ3-10)10-CpG vaccine can produce strong T helper 2 humoral immune responses, and avoid Aβ1-42-caused T helper 1 immune responses and Aβ1-42-induced cytotoxicity.
Therefore, Plp-Adeno-X-CMV-(Aβ3-10)10-CpG vaccine can be used as a novel type of AD vaccine. These findings were published in Neural Regeneration Research (Vol. 9, No. 8, 2014).
Source-Eurekalert