IITR00693 molecule was found to enhance the activity of antibiotics that are used in the treatment of bacterial infections.
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‘IITR00693 molecule has shown potent antibacterial activity against a wide range of gram-positive and gram-negative bacteria, including some of the most problematic drug-resistant strains. ’
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IITR00693 acts like a dual sword; it not only strikes down the most stubborn bacteria but also prevents the emergence of resistance, ensuring that it remains effective for generations to come, the researchers explained.
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IITR00693 Molecule to Fight Bacterial Infections
"We aimed to identify a small molecule that can potentiate currently used antibiotics. IITR00693, a novel antibacterial small molecule, potentiates the antibacterial activity of polymyxin B against Staphylococcus aureus and Pseudomonas aeruginosa," said Prof Ranjana Pathania, Department of Biosciences and Bioengineering, IIT Roorkee, in a statement.The team investigated in detail the mode of action of this interaction and the molecule's capability to combat soft-tissue infections caused by S. aureus and P.aeruginosa.
"The results indicate that IITR00693 has the highest safety index and efficacy. The synergy between IITR00693 and polymyxin B against Gram-positive S. aureus was intriguing, as polymyxin B is specifically active against Gram-negative bacteria," said Mahak Saini, Department of Biosciences and Bioengineering, IIT Roorkee.
The findings are published in the American Chemical Society Journal-ACS Infectious Diseases.
The team of researchers now aim to "further develop the molecule into a viable therapeutic agent that can be tested in clinical trials", said Prof K K Pant, Director, IIT Roorkee, in the statement.
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Source-IANS