![New Artificial Intelligence can Help Distinguish Between Two Lung Cancer Types New Artificial Intelligence can Help Distinguish Between Two Lung Cancer Types](https://images.medindia.net/health-images/1200_1000/lung-cancer-1.jpg)
‘A new computer program examines the images of patients lung tumors and can differentiate cancer types, identify the altered genes which drive the abnormal cell growth.’
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Such genetic changes or mutations often cause the abnormal growth seen in cancer, but can also change a cell's shape and interactions with its surroundings, providing visual clues for automated analysis.![twitter](https://images.medindia.net/icons/news/social/twitter.png)
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Determining which genes are changed in each tumor has become vital with the increased use of targeted therapies that work only against cancer cells with specific mutations, researchers say. About 20 percent of patients with adenocarcinoma, for instance, are known to have mutations in the gene epidermal growth factor receptor or EGFR, which can now be treated with approved drugs.
But the genetic tests currently used to confirm the presence of mutations can take weeks to return results, say the study authors.
"Delaying the start of cancer treatment is never good," says senior study author Aristotelis Tsirigos, Ph.D., associate professor in the Department of Pathology at NYU Langone's Perlmutter Cancer Center. "Our study provides strong evidence that an AI approach will be able to instantly determine cancer subtype and mutational profile to get patients started on targeted therapies sooner."
Machine Learning
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Newer AI approaches, inspired by nerve cell networks in the brain, use increasingly complex circuits to process information in layers, with each step feeding information into the next, and assigning more or less importance to each piece of information along the way.
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Interestingly, the study found that about half of the small percentage of tumor images misclassified by the study AI program was also misclassified by the pathologists, highlighting the difficulty in distinguishing between the two lung cancer types. On the other hand, 45 out of 54 of the images misclassified by at least one of the pathologist in the study were assigned to the correct cancer type by the machine learning program, suggesting that AI could offer a useful second opinion.
"In our study, we were excited to improve on pathologist-level accuracies, and to show that AI can discover previously unknown patterns in the visible features of cancer cells and the tissues around them," says co-corresponding author Narges Razavian, Ph.D., assistant professor in the departments of Radiology and Population Health. "The synergy between data and computational power is creating unprecedented opportunities to improve both the practice and the science of medicine."
Moving forward, the team plans to keep training its AI program with data until it can determine which genes are mutated in a given cancer with more than 90 percent accuracy, at which point they will begin seeking government approval to use the technology clinically, and in the diagnosis of several cancer types.
Source-Eurekalert