High levels of ketone bodies in the plasma of arrhythmogenic cardiomyopathy (AC) patients could serve as a reliable predictor of AC progression, said new study.
Cardiomyopathy - Dilated - Hypertrophic and Restrictive Types
Cardiomyopathy weakens the heart muscles and the heart loses strength to pump blood throughout the body. Treatment aims to improve symptoms and prevention complications.
Cardiomyopathy weakens the heart muscles and the heart loses strength to pump blood throughout the body. Treatment aims to improve symptoms and prevention complications.
‘Using both a mouse model of arrhythmogenic cardiomyopathy (AC) and cardiomyocytes derived from stem cells generated from AC patients, the researchers found further evidence for ketone-producing metabolic pathways as a hallmark of AC.’
Now, building on prior work that indicated metabolic abnormalities in the heart muscle of AC patients, Jiang-Ping Song and colleagues have found that high levels of ketone bodies in the plasma of AC patients could serve as a reliable predictor of AC progression. The researchers compared heart tissue from a cohort of 13 AC patients with heart tissue from 13 healthy donors and found increased expression of enzymes involved in ketone metabolism in the AC patients' hearts. They also compared plasma samples from AC patients, healthy volunteers, and patients diagnosed with other cardiopulmonary diseases, and found elevated levels of ketone bodies - especially β-hydroxybutyrate - in the AC patient samples.
In a final validation step, the researchers compared plasma from a cohort of 65 AC patients, 94 of their relatives, and 62 healthy volunteers, and found elevated β-hydroxybutyrate levels in the AC patients and some of their relatives. The findings suggest that β-hydroxybutyrate could serve as a reliable predictor of AC progression in those suspected to be at risk of the disease.
Test Your Knowledge on Coronary Heart Disease
Coronary heart disease is a direct consequence of today’s unhealthy lifestyle and food habits, which include a high-fat diet, inadequate exercise and loads of stress. Coronary heart disease is emerging as an epidemic of the modern world, affecting younger individuals and extending to poorer countries as well. Here is a quiz that will test your knowledge on basic terminology used in coronary heart disease.
Coronary heart disease is a direct consequence of today’s unhealthy lifestyle and food habits, which include a high-fat diet, inadequate exercise and loads of stress. Coronary heart disease is emerging as an epidemic of the modern world, affecting younger individuals and extending to poorer countries as well. Here is a quiz that will test your knowledge on basic terminology used in coronary heart disease.
Target Heart Rate During Exercise
Embarking on a fitness regime? Find out what your safe heart rate zone while exercising.
Embarking on a fitness regime? Find out what your safe heart rate zone while exercising.
Arrhythmogenic Cardiomyopathy: New Insights
Scientists have identified possible treatment breakthrough for the rare disease arrhythmogenic right ventricular cardiomyopathy.
Scientists have identified possible treatment breakthrough for the rare disease arrhythmogenic right ventricular cardiomyopathy.
