New Dementia Vaccine for Memory Loss Comes Closer to Reality

New vaccine to prevent memory loss is labeled revolutionary and expected to hit the market soon, said researchers.

Soon a new and preventive treatment for dementia may proceed to clinical trials after successful animal testing, say researchers.

Recent success in bigenic mice models supports progression to human trials in years to come, the research //added.

Dementia - Types, Causes, Symptoms, Diagnosis, Treatment
Dementia has become a very big concern as we have an aging population across the world. Dementia is also terrifying to us because of its disturbing symptoms and limited treatment options.

The study, published in the journal Alzheimer's Research & Therapy paves the way for more work in 2020 with medical researchers at the Institute for Molecular Medicine and University of California, Irvine (UCI) working with a successful vaccine formulated on adjuvant developed by Flinders University Professor Nikolai Petrovsky in Australia.

The researchers tested the universal MultiTEP platform-based vaccines formulated in the adjuvant developed at Australian lab.

The possible new therapies were tested in bigenic mice with mix Aß and tau pathologies.

Quiz on Memory Loss

“Without memory, there is no culture. Without memory, there would be no civilization, no society, no future.” - Elie Wiesel

Whether it is a short term memory loss just as Dory in 'Finding Nemo' had or a more permanent one because of neurodegenerative diseases, it can adversely affect one's quality of life. Take this quiz to know more about interesting facts on memory loss / amnesia.

"Taken together, these findings warrant further development of this dual vaccination strategy based on the MultiTEP technology for ultimate testing in human Alzheimer's disease," said the study lead authors Professor Anahit Ghochikyan and Mathew Blurton-Jones.

Professor Petrovsky said the Advax adjuvant method is a pivotal system to help take the combination MultiTEP-based Aß/tau vaccines therapy, as well as separate vaccines targeting these pathological molecules, to clinical trials - perhaps within two years.

Caring for Alzheimers disease patients
Alzheimer's disease is a complex brain disorder that triggers the most common form of dementia. The slide show will show how patients need support and care as dementia progresses.

"Our approach is looking to cover all bases and get past previous roadblocks in finding a therapy to slow the accumulation of Aß/tau molecules and delay Alzheimer's disease progression in a the rising number of people around the world," Petrovsky added.

Several promising drug candidates have failed in clinical trials so the search for new preventions or therapies continues.

Top 10 Interesting Facts About Dementia
Alzheimer's disease is the most common type of dementia, accounting for 60-70% of cases. Here are some interesting facts about dementia.

A recent report on human monoclonal antibody, aducanumab, showed that high dose of this antibody reduced clinical decline in patients with early Alzheimer's disease as measured by primary and secondary endpoints.

However, it is obvious that it could not be used as a preventive measure in healthy subjects due to the need for frequent (monthly) administration of high concentrations of immunotherapeutic.

There is a pressing need to keep searching for new preventive vaccine to delay Alzheimer's disease and slow down progression of this devastating disease.

The new combined vaccination approach could potentially be used to induce strong immune responses to both of the hallmark pathologies of Alzheimer's disease in a broad population base of vaccinated subjects with high MHC (major histocompatibility complex) class II gene polymorphisms, the study concluded.

Source-IANS