New Dialysis Device Effectively Treats Severe Liver Failure

A new dialysis device developed by researchers to treat individuals with severe liver failure is safe and effective.

The first in-patient trial, led by researchers of Indian-origin, has demonstrated the safety and effectiveness of a newly developed dialysis device for the treatment of severe liver failure.

Researchers, including those of Indian-origin, have led the first in-patient trial of a new dialysis device designed to treat severe liver failure, and the results demonstrate its safety and effectiveness.

Liver Failure - Types, Causes, Symptoms, Complications, Diagnosis, Treatment & Prevention
Liver failure occurs when the liver loses its ability to perform its normal functions of regeneration or repair. It can be a gradual or a sudden process.

‘The study found that the DIALIVE treatment resulted in a much faster recovery from ACLF (acute-on-chronic liver failure) compared to the standard treatment. #Liverfailure #LiverCirrhosis’

Acute-on-chronic liver failure (ACLF) affects around 30 percent of cirrhosis patients admitted to hospitals, resulting in over one million deaths worldwide annually. At present, liver transplantation is the sole potential treatment for this condition, but it is accessible to only a limited number of patients.

The new DIALIVE device was found to be safe and was associated with substantial improvement in the severity of symptoms and organ function in a greater proportion of patients with ACLF, when compared with patients receiving standard of care.

In the trial, 32 patients were treated with DIALIVE or standard of care for up to five days and the outcomes were recorded at days 10 and 28. The results showed that DIALIVE treatment was associated with significantly faster reversal of ACLF compared with standard of care, with ACLF resolving in about twice the number of patients.

Common Types of Liver diseases leading to Liver Transplantation
Liver disease that ends in liver failure (end stage liver disease), disrupting several important metabolic functions needs liver transplant for patient survival.

DIALIVE treatment also led to a significant reduction in endotoxins, which are released when bacteria die, and improved albumin function.

"It gives me enormous pleasure to see the promise of this novel liver dialysis device for the treatment of acute-on-chronic liver failure," said Dr Banwari Agarwal, Chief Investigator of the DIALIVE trial from the Royal Free Hospital, UK ().

DIALIVE could be Approved for Clinical Use after Next Trial

The intervention has the potential to transform the care provided to the ever-increasing number of patients and their families suffering from the effects of living with what is essentially a terminal illness for many.

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"It has the potential to transform the therapeutic options available to clinicians across the world for patients with ACLF," said Agarwal, also the Associate Professor at the University College London.

Further, the trial results also showed improvements in biomarkers of systemic inflammation, such as cytokines, endothelial function and markers of cell death. Despite receiving as little as three days' treatment, patients whose ACLF resolved remained in remission for 28 days afterwards.

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The next step will be a larger clinical trial, which if successful could see DIALIVE approved for clinical use within the next three years, said researchers at UCL's Institute for Liver and Digestive Health, who invented the device.

Worldwide, it is estimated that there are around 100 million people living with cirrhosis of the liver and 10 million who have cirrhosis plus an additional complication. round three million of those individuals have ACLF, a condition that can cause liver function to suddenly decline, placing individuals at high risk of short-term death.

Reference:

UCL invented dialysis machine proved safe and effective for treating liver failure - (https://www.ucl.ac.uk/news/2023/may/ucl-invented-dialysis-machine-proved-safe-and-effective-treating-liver-failure)

Source-IANS