Metastatic castration-resistant prostate cancer usually remains untreatable and fatal. The new treatment, known as Lu-PSMA-617, could help treating patients with this condition.
New treatment combats late stage prostate cancer by delivering beta radiation directly to tumour cells. It is well tolerated by patients and keeps them alive for longer compared to standard care, as per the phase 3 trial findings. New approach, targets a molecule called PSMA, which is known to be increased on the surfaces of the tumour cells, destroying them and their surrounding microenvironment.
‘Lu-PSMA-617 can improve the lives of many men with advanced prostate cancer and their families.’
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International team of researchers set out to see whether Lu-PSMA-617 was more effective than standard care and recruited 831 patients with metastatic castration-resistant prostate cancer between June 2018 and October 2019. Patients were randomized to receive the treatment plus standard care or standard care alone.Read More..
The treatment significantly improved survival of patients by an average of four months, compared with standard treatment. Median survival time was 15.3 for the treatment group and 11.3 months for those receiving standard care.
Progression-free survival was also longer with the treatment: a median of 8.7 months compared with 3.4 months for those with standard care.
It is an effective and safe medicine that can improve standard of care for patients with this advanced prostate cancer.
Professor Ken Herrmann says: "This is a completely new therapeutic concept; a precision medicine that delivers radiation directly to a high incidence tumour. The treatment was well tolerated by patients and they had an average of four months' longer survival with good quality of life. Lu-PSMA-617 can improve the lives of many men with advanced prostate cancer and their families."
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Currently, the treatment is being appraised by the National Institute for Health and Care Excellence (NICE) for use in the NHS in England and Wales."
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"LU-PSMA-617 was tested in so-called end-stage disease and still showed superiority and this paves the way for studies to treat patients in earlier stages. We have seen similar success in the diagnostic setting, using this molecule to improve the way we stage tumours. This targeted approach will revolutionise the way we approach the treatment of men with prostate cancer in the future."
Source-Medindia