Adding the new targeted antibody olaratumab (Lartruvo) in combination with doxorubicin improves progression-free survival in patients with advanced sarcomas.
Ewing Sarcoma Tumor Growth Accelerated by Single Genetic Abnormality
Bone cancer Ewing sarcoma is driven by a genetic abnormality that operates through two distinct processes, activating genes that stimulate tumor growth and suppressing those that prevent cancer.
Bone cancer Ewing sarcoma is driven by a genetic abnormality that operates through two distinct processes, activating genes that stimulate tumor growth and suppressing those that prevent cancer.
‘Patients with advanced sarcomas that have metastasized or that cannot be cured with surgery are commonly treated with doxorubicin chemotherapy.’
Oncologist Dr. Arun Singh is an assistant professor and co-director of the sarcoma program in the division of hematology/oncology in the David Geffen School of Medicine at UCLA. Dr. Singh's research is focused on developing novel therapies for patients with sarcomas. Dr. Singh can discuss clinical trials for sarcoma patients and immunotherapeutic approaches for managing these diseases. He can also explain what the recent FDA approval of olaratumab (Lartruvo) means for sarcoma patients and how this recent decision could change the way oncologists use traditional methods such as chemotherapy, radiation therapy and surgery to treat people with the disease.
"The Food and Drug Administration's recent approval of this sarcoma combo treatment happened during an exciting time," says Singh. "I'm currently an investigator of a large ongoing phase 3 clinical trial, and if the results are positive, the findings will continue to advance the standard of care for patients with advanced soft tissue sarcomas."
Two Mutations Linked to Ewing Sarcoma Subtype With Poor Prognosis
Frequent mutations in two genes that often occur together in Ewing sarcoma (EWS) have been identified by an international collaboration.
Frequent mutations in two genes that often occur together in Ewing sarcoma (EWS) have been identified by an international collaboration.
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Experimental Breast Cancer Drug Could Work for Ewing Sarcoma
A combination therapy that included drugs from a family of experimental agents developed to fight breast cancer was administered on mice with Ewing sarcoma tumors.
A combination therapy that included drugs from a family of experimental agents developed to fight breast cancer was administered on mice with Ewing sarcoma tumors.
Kaposi's Sarcoma Treatment Gets a New Clue
The search for an efficient treatment for a type of cancer-causing herpes, known as Kaposi's sarcoma gets a new clue with the Herpes virus proteins behaving more spaghetti-like than presumed
The search for an efficient treatment for a type of cancer-causing herpes, known as Kaposi's sarcoma gets a new clue with the Herpes virus proteins behaving more spaghetti-like than presumed
