New, Effective Platinum-based Anti-tumour Drugs Developed

Scientists have developed a new class of platinum-based anti-tumour drugs that animal studies have shown to be 10 times more effective than current treatments in destroying certain

Scientists have developed a new class of platinum-based anti-tumour drugs that animal studies have shown to be 10 times more effective than current treatments in destroying certain types of lung cancer cells.

The animal study, conducted by researchers in the Department of Chemistry at Wake Forest University in collaboration with colleagues at the Wake Forest University Health Sciences Comprehensive Cancer Center, suggests a new approach to fighting non-small cell lung cancer, which accounts for more than three-quarters of all lung cancers.

Lung Cancer - Types, Causes, Symptoms, Diagnosis, Treatment and Prevention
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.

"We are able to slow the growth of this cancer substantially in mice. That is very good news, since this is such a rapidly growing, intractable type of cancer," said principal investigator Ulrich Bierbach, Z. Smith Reynolds Foundation Fellow and associate professor of chemistry at Wake Forest.

The new compound's potency derives from its ability to rapidly bind with and disable a tumour cell's DNA before the cell's natural repair mechanisms are activated.

That repair process causes drug resistance, which reduces the effectiveness of currently used platinum-based drugs.

Lung Biopsy - Indications - Procedures - Risks - FAQs - Reference
The procedure by which tissue samples are obtained from the lung is known as lung biopsy. The biopsy tissues obtained from the lungs are examined by a pathologist.

Bierbach has focused his research efforts since 1992 on finding ways to overcome the resistance problems inherent in platinum-based drugs.

"If this ends up in clinical trials in the next few years, that will fulfill a dream of mine," Bierbach said.

Green Tea May Block Efficacy Of Cancer Drug
The health benefits of green tea have come under scanner following a new research which has found that the healthy drink could reduce the effectiveness of one kind of chemotherapy treatment.

His research efforts will now be directed toward finding ways to boost the tumour-killing potency of the new compounds while reducing harmful side effects.

The results were published in the December 11 issue of the Journal of Medicinal Chemistry and highlighted in Science-Business eXchange (SciBX), produced by the publisher of the journal Nature.

Combination Drug Therapy Could Revolutionise Cancer Cure
Scientists in Melbourne have given cancer patients a ray of hope after they found that a new combination drug therapy would revolutionize the treatment for the deadly disease.

Source-ANI
SRM