In hepatocellular carcinoma, a combination of mTOR inhibitors and Phenformin lead to an increase in overall survival.
Current Treatments for Liver Cancer | Hepatoma | Hepatocellular Carcinoma
Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early.
Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early.
‘In hepatocellular carcinoma, a combination of mTOR inhibitors and Phenformin lead to an increase in overall survival.’
"Currently available therapeutic options for HCC are very limited and offer poor outcomes, prompting the search for new therapeutic approaches", explains Dr. Kozma, last author of the article. "Inhibitors of the mTOR pathway had already been explored as an alternative treatment, given that this pathway is hyperactivated in most HCCs, but they showed little clinical efficacy. However, as recent data suggested that mTOR inhibitors may promote cancer cell survival by maintaining mitochondrial oxidation and/or autophagy, we set out to examine their use combined with inhibitors of mitochondrial activity." she adds. In their study, researchers show that treatment of HCC cells in vitro with Phenformin, a mitochondrial Complex1 inhibitor, causes a metabolic shift to glycolysis, mitochondrial dysfunction and fragmentation. "These changes sensitize orthotopic liver tumors in mice to dual inhibition of mTOR, which improves tumor-bearing mice overall survival", says Dr. Sonia Veiga, first author of the Clinical Cancer Research paper.
"Given the recent approval of Phenformin in a clinical trial for melanoma, it will be exciting to explore this regimen clinically in HCC", says Dr. Kozma. According to Dr. Veiga, next steps include testing this combination in human samples thanks to collaboration with Bellvitge Unversity Hospital and the Catalan Institute of Oncology, as well as comparing the results obtained with those of current treatments for HCC.
Liver Cancer - Types, Causes, Symptoms, Diagnosis, Treatment, Prevention, Progosis
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
Test Your Knowledge on Liver Cancer
Primary hepatocellular carcinoma is a cancer that starts in the liver. The liver is the largest organ in the body situated in the upper right quadrant of the abdomen. The liver is also a common site for cancer deposits (metastases) from other organs. This is referred to as secondary liver cancer and is more common than primary liver cancer.
Primary hepatocellular carcinoma is a cancer that starts in the liver. The liver is the largest organ in the body situated in the upper right quadrant of the abdomen. The liver is also a common site for cancer deposits (metastases) from other organs. This is referred to as secondary liver cancer and is more common than primary liver cancer.
Liver Cancer
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it’s symptoms are presented in this interactive.
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it’s symptoms are presented in this interactive.
