Researchers at Oregon Health and Science University, Portland, have shed new light on the role of the signaling molecule Smad2 in skin cancer.
The role of the signaling molecule Smad2 in skin cancer has been explained in detail by researchers at Oregon Health and Science University, Portland.
Xiao-Jing Wang and colleagues from the university provided the new insights by analysing human skin cancer tissue and a mouse model of skin cancer.
Skin Cancer - Types, Causes, Symptoms, Diagnosis, Treatment & Prevention
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun over the years.
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun over the years.
In particular, Smad2 expression was lost in all samples characterized as 'poorly differentiated' (which means they had progressed to become aggressive tumours).
Consistent with this, mice lacking Smad2 in cells of the skin known as keratinocytes developed chemically induced skin cancer more rapidly than normal mice, and the cancers were all characterized as 'poorly differentiated'.
Skin Biopsy-Procedure-Punch-Shave-Incisional-FAQ-Video
Encyclopedia section of medindia gives general information about skin biopsy.
Encyclopedia section of medindia gives general information about skin biopsy.
These data identify Smad2 as a suppressor of skin cancer development and progression to an aggressive form, and future studies will investigate in more detail the mechanisms underlying the role of Smad2 loss in human skin cancer progression.
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Scalp and Neck Melanoma More Dangerous
It seems that those who have melanoma on their scalp or neck are less likely to survive for five or ten years when compared to those who have melanoma at other sites.
It seems that those who have melanoma on their scalp or neck are less likely to survive for five or ten years when compared to those who have melanoma at other sites.
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Stay Safe From the Summer Sun
Sun exposure has its benefits—it increases vitamin D levels in the body and prevents insomnia and depression but too much can trigger skin cancer, cataracts, wrinkles, sagging skin, and age spots.
Sun exposure has its benefits—it increases vitamin D levels in the body and prevents insomnia and depression but too much can trigger skin cancer, cataracts, wrinkles, sagging skin, and age spots.
