Treatment approaches for familial hypercholesterolemia, a hereditary genetic disorder in the pediatric population are multidisciplinary and aim to reduce total cardiovascular risk.
High Cholesterol | Hypercholesterolemia - Causes, Symptoms, Diagnosis & Treatment
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the wall of the arteries and clog the circulation posing a threat to life.
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the wall of the arteries and clog the circulation posing a threat to life.
‘Diagnosis of familial hypercholesterolemia in children and adolescents is usually based on clinical phenotype upon LDL-C levels and family history of premature cardiovascular and/or elevated LDL-C.’
Treatment approaches for familial hypercholesterolemia in the pediatric population are multidisciplinary and aim to reduce total cardiovascular risk. The most widely recommended and effective pharmacotherapy in the pediatric age group is currently statins. Ezetimibe and bile acid sequestrants are usually used as second-line agents. Evidence would be expected in the near future by cohort and registry studies.The main gap of evidence remains the lack of longitudinal follow up studies investigating cardiovascular outcomes, side effects, and effectiveness of treatment starting from childhood.
Source-Eurekalert
Gardner Syndrome | Familial Adenomatous Polyposis (FAP) - Causes, Symptoms, Diagnosis, Treatment and Risk Factors
Gardner or Gardner's syndrome, also known as familial adenomatous polyposis (FAP), is an autosomal dominant genetic disease. It is characterized by growth of polyps in the colon, which develop into colon tumors.
Gardner or Gardner's syndrome, also known as familial adenomatous polyposis (FAP), is an autosomal dominant genetic disease. It is characterized by growth of polyps in the colon, which develop into colon tumors.
Atherosclerosis - Causes, Symptoms, Prevention & Treatment
Atherosclerosis is a condition in which the arteries become hard and narrow, leading to restricted blood flow.
Atherosclerosis is a condition in which the arteries become hard and narrow, leading to restricted blood flow.
Quiz on Genetic Disorders
Genetic disorders include a variety of diseases that are caused by abnormalities or defects in the DNA. Abnormalities in genes are referred to as genetic mutations and these mutations may be small, affecting just one gene or affecting entire chromosomes. Such mutations may develop spontaneously or they may be inherited from either parent. The consequences of such genetic disorders can vary greatly and very often the extent to which a genetic condition affects the person will be influenced by environmental factors as well. Test your knowledge on genetic disorders by taking this quiz.
Genetic disorders include a variety of diseases that are caused by abnormalities or defects in the DNA. Abnormalities in genes are referred to as genetic mutations and these mutations may be small, affecting just one gene or affecting entire chromosomes. Such mutations may develop spontaneously or they may be inherited from either parent. The consequences of such genetic disorders can vary greatly and very often the extent to which a genetic condition affects the person will be influenced by environmental factors as well. Test your knowledge on genetic disorders by taking this quiz.
