New Insights into Oral Malignancy

Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.

A new research has discussed the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy in relation to immune check point inhibitors, regulatory T cells (Treg), myeloid-derived suppressor cells (MDSCs) and cancer associated fibrobla.

In addition, the therapeutic approach of oral pre-cancerous disorders is mentioned. Some reports also advocate that the immunosuppressive efficacy of the oral squamous cell carcinoma (OSCC) milieu is developed in a stepwise manner depending on the stages of OSCCs. Namely, in the early stage, CAFs could be a unique effector; humoral factor(s) from OSCC cells force CAF to exert immune suppression via the direct cell contacts to effector T cells.

Oral Cancer | Mouth Cancer - Types, Causes, Symptoms, Diagnosis, Treatment & Prevention
Oral cancer is a cancer that develops in any part of the mouth. It is more common in men over 40.

‘Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.’

Potentiated CAF could also affect other immune-suppressive mediators such as Treg, tumor-associated macrophages (TAMs) and MDSCs. In the advanced stage of OSCC, MDSCs could possibly be a major conductor of immune-suppression.

However, how OSCCs differentially utilize the immune modulatory aspects involving CAFs, MDSCs and several other factors is not fully understood. Further elucidation of the regulatory pathways structured by tumor-host interactions could identify important therapeutic targets in OSCC development.

Source-Eurekalert

Quiz on Oral Cancer
Oral cancer refers to abnormal growth of cells that are malignant in nature in the oral cavity. Test your knowledge on oral cancer by taking this quiz.

First ever Independent Oral Cancer Task Force in India
Independent Oral Cancer Task Force has been set up in India on the World Cancer Day (4th February, 2018) to help control oral cancer in India in the next ten years.

Biocon's Chairperson Kiran Mazumdar-Shaw Joins National Body to Fight Oral Cancer
Oral cancer is said to be one of the most common forms of cancer occurring among Indian men. Oral Cancer Task Force is aimed to fight oral cancer and reduce oral cancer risks.