Liver damage can be triggered by various insults, including hepatitis infection or alcohol-induced cirrhosis.
Liver damage can be triggered by various insults, including hepatitis infection or alcohol-induced cirrhosis. In severe cases, this damage can lead to cancer. A new study by researchers at the National Institutes of Health and Osaka University reveals how one protein helps decide the fate of damaged livers in mice. The study will be published online on March 30th in the Journal of Experimental Medicine.
Liver cells rely on signals triggered by growth hormone to survive and multiply—functions that go haywire in cancer. Normally, growth hormone works by activating a signaling network inside liver cells that includes a protein called STAT5. When the researchers removed STAT5 from liver cells, cancer ensued.
Liver Cancer - Types, Causes, Symptoms, Diagnosis, Treatment, Prevention, Progosis
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
TGFbeta and STAT5 appear to be adversaries in the liver, according to the study. STAT5 protects the liver by breaking down TGFbeta. But when TGFbeta is abundant—as occurs in people with chronic liver damage—growth hormone activates the cancer-promoting STAT3 instead of the protective STAT5. These results might help explain how chronic liver damage can eventually lead to cancer.
Source-Eurekalert
SRM
Liver Cancer Treatment
Liver Cancer is the uncontrolled growth of cells in the liver. The present section provides a graphic description of the various forms of liver cancer treatment in addition to the latest techniques such as Chemoembolisation and Radio frequency Ablation.
Liver Cancer is the uncontrolled growth of cells in the liver. The present section provides a graphic description of the various forms of liver cancer treatment in addition to the latest techniques such as Chemoembolisation and Radio frequency Ablation.
Alcoholic Liver Disease - Causes Symptoms Diagnosis Treatment FAQs
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
Hepatitis B-Causes-Symptoms-Diagnosis-Treatment-Vaccination-FAQs
Hepatitis B is inflammation of the liver due to infection with the hepatitis B virus.
Hepatitis B is inflammation of the liver due to infection with the hepatitis B virus.
