New way to stop tumors from shedding certain proteins that the immune system uses to identify and attack tumors identified. The new method reduces the spread of melanoma and lung cancer in mice.
Melanoma - Causes, Symptoms, Diagnosis, Treatment & Prevention
Melanoma of the skin is a dangerous type of skin cancer that usually appears as a cancerous mole due to exposure to the sun’s damaging UV rays.
Melanoma of the skin is a dangerous type of skin cancer that usually appears as a cancerous mole due to exposure to the sun’s damaging UV rays.
‘New way to stop tumors from shedding certain proteins that the immune system uses to identify and attack tumors has been identified by scientists.’
In an act of defiance, cancer cells produce enzymes that cleave these anchored proteins, essentially shedding the proteins and evading detection.
Lucas Ferrari de Andrade et al. suspected that it would be possible to stop tumors from shedding these proteins using antibodies that target the site where MICA and MICB proteins are cleaved. They studied the effect of such an antibody, mAb 7C6, in mouse models of melanoma and lung cancer, finding that the antibody not only increased the presence of MICA and MICB on cancer cells, but also increased the infiltration of natural killer cells within tumors. In mice with metastatic melanoma that had spread to the lungs, treatment with mAb 7C6 helped reduce tumor load, the authors report. In a related Perspective, Adelheid Cerwenka and Lewis Lanier write, "The study introduces an exciting concept for a therapeutic monoclonal antibody with the potential to improve natural killer cell-based cancer immunotherapy."
Source-Eurekalert
Lung Cancer - Types, Causes, Symptoms, Diagnosis, Treatment and Prevention
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
Quiz on Lung Cancer (Advance)
Lung cancer, like other cancers, is a dreaded condition responsible for a number of deaths in both men and women. Test your knowledge on lung cancer by taking this quiz.
Lung cancer, like other cancers, is a dreaded condition responsible for a number of deaths in both men and women. Test your knowledge on lung cancer by taking this quiz.
Test your Knowledge on Moles and Melanoma
Melanoma is a skin condition that is often a consequence of excessive exposure to the sun’s ultraviolet radiation. Test your knowledge on melanoma by taking this quiz.
Melanoma is a skin condition that is often a consequence of excessive exposure to the sun’s ultraviolet radiation. Test your knowledge on melanoma by taking this quiz.
