New Promising Target to Treat Binge Eating Identified

Brain area associated with motivational disruptions in binge eating is identified. Orexin neurons, a small group of brain cells in the hypothalamus can be a potential target for medications for controlling binge eating episodes in individuals with obesity.

Brain area associated with binge eating is identified. A small group of brain cells in the hypothalamus could be a potential target for medications for controlling binge eating episodes in individuals with obesity, reports a new study.

The researchers said that "orexin" neurons -- named for the chemical messenger they use to communicate with other brain cells -- have previously been shown to be important for addiction to several drugs including cocaine.

Binge Eating Disorder | Compulsive Overeating Disorder - Causes, Symptoms, Complications & Treatment
When a person overeats, he is unable to control his hunger pangs, while during an emotional/binge eating session, he is incapable of controlling his emotions.

‘Brain area associated with binge eating is identified. Small group of brain cells in the hypothalamus called 'orexin' neurons can be a potential target for medications for controlling binge eating episodes in individuals with obesity.’

"Several key symptoms of eating disorders, such as the sense of losing control, overlap with what we know about the driven nature of drug addiction," said co-author Gary Aston-Jones from Rutgers, The State University of New Jersey in the US.

"Since the orexin system has been implicated in addiction to drugs of abuse, we targeted it to understand the change in food motivation caused by repeated episodes of binge eating," Aston-Jones added.

For the study, presented at the 26th Annual Meeting of the Society for the Study of Ingestive Behavior, the researchers examined female rats fed a control diet or a sugary, high-fat diet that causes weight gain and binge eating patterns.

Impact of Binge Eating on Weight Loss
Individuals who have stopped binge eating or had a reduced tendency to binge eat lost more body weight than those who continued binge eating.

Then the researchers set up a task where rats could work to earn sweet treats.

The researchers found that as the work required increased, persistent motivation to earn the treat was seen only in the binge-eaters who had previously gained weight on a high-fat diet.

Overeating Equals To Overcheating
Stuffing your tummy with unwanted extra calories can have a negative impact on the body. Overeating means frequent intake of food even when not hungry.

According to the researchers, notably, this enhanced motivation was reversed by treatment with a compound that blocks orexin signals in the brain.

"This study was really a proof-of-concept for using orexin blockers to reduce binge-like eating in rodents," said the lead author Morgan James from Rutgers, The State University of New Jersey.

Decline of Binge Eating from Adolescence to Adulthood
People with binge eating are usually depressed and suffer from stress and difficulty in sleeping. Ailments like high blood pressure, type 2 diabetes, etc. are linked with binge eating.

The researchers also found that the orexin blocker reduced the amount of food consumed during the binge eating episodes, where rats were given unrestricted access to a sweetened fat mixture over a 30 minute period.

Source-IANS