New Strategy to Defeat HIV in South Africa

The World Health Organization is about to roll out a best strategy for curbing HIV.

The World Health Organization is about to roll out a best strategy for curbing HIV. Based on a mathematical model, the WHO predicts this strategy will completely eliminate HIV in South Africa within a decade.

But not so fast, suggests a group of UCLA researchers. Their work challenges the proposed strategy by showing it could lead to several million individuals developing drug-resistant strains of HIV. And further, they say, it will cost billions of dollars more than the WHO has estimated.

AIDS/HIV - Kaposi's sarcoma
Kaposi sarcoma develops below the skin surfaces or in mucous membranes of mouth, nose or anus and appears as lumps

Reporting in the current issue of the journal PloS ONE, senior author Sally Blower, director of the UCLA Center for Biomedical Modeling, and first author Bradley Wagner, a postdoctoral scholar in Blower''s lab, used sophisticated computer modeling to evaluate the WHO''s proposed strategy.

"By developing our own mathematical model and reevaluating the WHO''s proposed strategy for South Africa, we found the WHO''s predictions are wrong," Blower said.

"This is because their model is unrealistic," Wagner added. "If you use an unrealistic model, you get the wrong answer."

Quiz on HIV Symptoms
Do you know that there are symptoms for each stage of HIV/AIDS? Learn more from our HIV Symptom Quiz but here’s a disclaimer – never go by symptoms alone. Symptoms only indicate the progression of the disease, while only a medical test can confirm it.

The method under debate is the WHO''s universal "test and treat" strategy. This strategy is based on testing the entire population of South Africa annually for HIV, then treating every individual immediately after infection, before they develop symptoms. "Test and treat" uses treatment as a method of prevention, as treatment makes individuals less infectious. It would mean treating nearly 5 million individuals in South Africa almost immediately, the UCLA researchers say.

The WHO model predicts "test and treat" would be better than only treating the 1.6 million people in South Africa who have symptoms and actually need treatment. The organization''s model predicts that treating the 1.6 million alone would not eliminate HIV and, over 40 years, such an approach would be more expensive than the "test and treat" strategy.

HIV/AIDS Risk Calculator
The HIV risk quiz helps you determine risk factors for HIV.

"But," Blower said, "our model shows the opposite."

"Our model shows that providing treatment to the 1.6 million people who are in need of treatment would be very effective as a form of ''treatment as prevention,''" said Wagner. "It could bring the HIV epidemic in South Africa close to elimination and prevent 11 million infections over the next 40 years. Our model also shows the WHO''s ''test and treat'' strategy would actually cost $12 billion more than providing treatment to the 1.6 million in need."

A Step Closer to Vaccine Against HIV That Causes AIDS
Scientists report new insights into how a family of rare, highly powerful antibodies bind to HIV and neutralize it to prevent it from infecting human cells and this could herald a new HIV vaccine.

"The difference between our results and those of the WHO is because we assume that drug-resistant strains can develop in treated individuals, and therefore they will need more expensive ''second-line'' drugs," Blower said. "The WHO assumes drug resistance will not evolve, and, essentially, there will be no need for ''second-line'' drugs."

The UCLA researchers said they agree that the WHO''s "test and treat" strategy would indeed prevent many infections. But realistically, that strategy would require substantial financial resources and a robust health infrastructure. Unfortunately, they say, such resources are not available.

"Before implementing a ''test and treat'' strategy, we recommend trying to provide treatment for all those in need as quickly as possible," said Wagner. "This is desperately needed in South Africa."

Blower added, "If we could provide treatment to the 1.6 million people in need, it would increase their life expectancy by several decades and also save millions of lives. And this is a strategy that can be implemented immediately."

Funding for the study was provided by the National Institutes of Health and the National Institute of Allergy and Infectious Disease.

The Semel Institute for Neuroscience and Human Behavior is an interdisciplinary research and education institute devoted to the understanding of complex human behavior, including the genetic, biological, behavioral and sociocultural underpinnings of normal behavior and the causes and consequences of neuropsychiatric disorders. In addition to conducting fundamental research, institute faculty members seek to develop effective strategies for the prevention and treatment of neurological, psychiatric and behavioral disorders, including improvements in access to mental health services and shaping of national health policy.

Source-Newswise