New Target for Alzheimer's Drug Development Discovered

University of Minnesota's Center for Drug Design researchers have discovered a new synthetic compound that prevents the neurodegeneration associated with Alzheimer's disease.

In the pre-clinical study, researchers Robert Vince, Ph.D.; Swati More, Ph.D.; and Ashish Vartak, Ph.D., of the University's Center for Drug Design, found evidence that a lab-made compound known as psi-GSH enables the brain to use its own protective enzyme system, called glyoxalase, against the Alzheimer's disease process.

Alzheimer’s disease - Causes, Symptoms, Diagnosis, Stages, Types, Prevention, Prognosis & Treatment
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.

The discovery is published online in the American Chemical Society journal ACS Chemical Neuroscience and presents a new target for the design of anti-Alzheimer's and related drugs.

"While most other drugs under development and on the market attempt to slow down or reverse the Alzheimer's processes, our approach strikes at a root cause by enabling the brain itself to fight the disease at a very early stage," said Vince, the study's lead researcher and director of the Center for Drug Design. "As is the case with all drug development, these studies need to be replicated in human patients before coming to any firm conclusions."

Alzheimer's has previously been found to impair the ability of the brain to use the glyoxalase system. But the compound psi-GSH provides the glyoxalase system the fuel it needs to destroy destructive oxidized sugar metabolites that – in Alzheimer's models – converts normal brain amyloid protein into the abnormal form that produces Alzheimer's.

Quiz On Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common form of dementia. Participate in this quiz to find out how much you know about this debilitating disease.

When given to mice genetically predisposed to develop Alzheimer's disease, psi-GSH reduced the buildup of abnormal amyloid beta protein in the brain. The buildup of this protein is a well-known feature of Alzheimer's, ultimately found in the form of plaques and tangles in the brain associated with the condition.

After being administered with psi-GSH for 11 weeks, cognitive capabilities such as memory and chemical brain health indicators in Alzheimer's-predisposed mice remained intact.

Caring for Alzheimers disease patients
Alzheimer's disease is a complex brain disorder that triggers the most common form of dementia. The slide show will show how patients need support and care as dementia progresses.

For example, the treated mice retained complete memory in a standard Alzheimer's maze test while the untreated mice lost significant memory and ability to negotiate the maze, indications consistent with symptoms of advanced Alzheimer's.

In addition, the treated mice were devoid of brain plaques while the untreated mice had significant plaque formation.

Alzheimer Disease Evaluation may be Possible Via Amyloid Imaging
New research indicates that a test to detect brain amyloid deposits associated with Alzheimer disease (AD) can provide useful information to doctors.

Preliminary studies indicated no observed toxicity to the brain or other vital organs from psi-GSH.

Source-Eurekalert