New approach of mixing two medicines typically associated with malaria and melanoma can treat pancreatic tumors with KRAS mutations, said researchers.
Pancreatic Cancer - All About the Disease, its Diagnosis and Management
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
‘Scientists have discovered a combination drug therapy that may effectively combat pancreatic cancer. ’
"In publishing how this new approach of mixing two medicines typically associated with malaria and melanoma can treat pancreatic tumors with KRAS mutations, we are hoping the clinical trial supported by the Pancreatic Cancer Collective's New Therapies Challenge Grant will help us learn how to best administer these medicines, so that we can maximize the benefit for as many patients as possible," said Dr. Tuveson. "Dr. McMahon's research shows promise as an important advance and was selected in the Pancreatic Cancer Collective as part of the "New Therapies Challenge" for support for further validation as therapy. In this Challenge program, a second round of funding, up to $4 million, is possible to support additional clinical studies to bring new treatments to patients faster," added Phillip A. Sharp, PhD, the Nobel laureate who is chair of SU2C Scientific Advisory Committee (SAC) and scientific co-leader of the Collective.
Dr. McMahon's project, "Pancreatic Cancer Collective Research Team: Combined Targeting of MEK1/MEK2 and Autophagy for Pancreatic Cancer" will work toward two goals: 1) elucidating the mechanism(s) by which autophagy is regulated by the RAS pathway, in order to identify predictive biomarkers and new autophagy inhibitors that might be tested in clinical trials; and 2) performing a clinical trial of the T/HCQ combination therapy.
Quiz on Pancreatic Cancer
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Tongue Microbiome Could Help Early Detection of Pancreatic Cancer
Tongue coat microbiome is altered in pancreatic cancer patients. The change in the degree of colonization of bacteria could help in developing rapid diagnostic methods for early detection of pancreatic cancer.
Tongue coat microbiome is altered in pancreatic cancer patients. The change in the degree of colonization of bacteria could help in developing rapid diagnostic methods for early detection of pancreatic cancer.
New Combination Blood Test Helps Early Detection of Pancreatic Cancer
A simple blood test in combination with an existing test help identify pancreatic cancer well before the advanced and difficult-to-treat stages.
A simple blood test in combination with an existing test help identify pancreatic cancer well before the advanced and difficult-to-treat stages.
