New Treatment for Hyperkalemia (High Blood Potassium) Identified

A new study sheds light on treating and managing hyperkaleemia (too much potassium in the blood). Hyperkalemia may cause respiratory muscle weakness.

A new study sheds light on treating and managing hyperkalemia (too much potassium in the blood). Hyperkalemia may cause respiratory muscle weakness and potentially fatal heart rhythm disturbance.

“We found that there is a paucity of data on the knowledge and practice patterns of medical specialists regarding the emergency management of hyperkalemia. There is also a lack of consensus regarding the best way to manage it, which may result in wide variations in practice and the guidance provided to junior staff,” says Dr. Yazied Chothia, senior lecturer and nephrologist at SU’s Faculty of Medicine and Health Sciences.

Drug-Induced Hyperkalemia | High Potassium Levels
Intake of drugs like ACE inhibitors, angiotensin receptor antagonists, NSAIDs, certain antibiotics and immunosuppressants increase potassium levels in blood leading to hyperkalemia.

‘The researchers add that nephrologists tended to start therapy at a higher range of serum potassium/potassium in the blood (6,0–6,5 millimoles per litre [mmol/L]), defined by many as moderate to severe hyperkalemia.’

He conducted the research with colleagues Prof Usuf Chikte (Division of Health Systems and Public Health, Department of Global Health) and Dr. Razeen Davids (Division of Nephrology, Department of Medicine).

They conducted the first comprehensive survey in South Africa among specialists in nephrology, internal medicine, emergency medicine, and critical-care medicine to evaluate their knowledge regarding the diagnosis and management of hyperkalemia, with a focus on insulin-based therapy.

Insulin-based Therapy for Hyperkalemia

Insulin-based therapy is the most favored pharmacological method for treating hyperkalemia. Dextrose (a type of sugar) is usually co-administered to prevent low blood sugar (hypoglycemia).

Hyperkalemia | High Blood Potassium - Causes, Symptoms, Diagnosis, Treatment and Prevention
Hyperkalemia is a high level of potassium in the body. When potassium in the blood is above 5.5 mmol/l, it is called hyperkalemia and can lead to fatal changes in heart rhythm.

“Our aim was to identify knowledge gaps and to inform the development of learning resources to guide the optimal management of this life-threatening condition.”

The findings of their study were published recently in the African Journal of Nephrology.

Rapid Correction of Hyperkalemia Reduces Mortality by Half
Quickly correcting high potassium levels, a condition called hyperkalemia, in emergency department patients cuts death risk in that population by half, reports a new study.

According to the researchers, various recommendations exist regarding the dosing, sequence and rates of administration for insulin and dextrose to treat hyperkalemia.

They identified important shortcomings regarding the knowledge and management of hyperkalemia among medical specialists.

Zirconium Cyclosilicate Lowers High Potassium Levels Associated With Potentially Lethal Cardiac Arrhythmias
Mikhail Kosiborod, M.D., of Saint Luke's Mid America Heart Institute, Kansas City, and colleagues evaluated the safety and efficacy of the drug zirconium cyclosilicate in hyperkalemia (higher than normal potassium levels) patients.

“These included tented T waves as the most common electrocardiogram (ECG) change (change in heart rhythm) to trigger therapy, the time for the potassium concentration to reach its nadir following insulin administration, whether the potassium concentration would return to its pre-shift value and when this was expected to occur, defining resistant hyperkalemia, and the expectation and surveillance of hypoglycaemia following insulin-based therapy.

“Two-thirds of respondents routinely performed an ECG before deciding whether a patient required treatment for hyperkalemia, with more non-nephrologists performing an ECG. Nearly three quarters of respondents thought that there was a poor correlation between potassium and the presence of ECG changes.”

“We speculate that this is because of the high frequency with which they encounter patients with severe hyperkalemia.

“Regarding pharmacological therapy, all the respondents indicated that they regarded insulin and dextrose therapy as the most effective and reliable method for shifting potassium into cells. This was not surprising because insulin-based therapy is regarded by most authorities as the cornerstone of treatment.”

According to researchers, fewer than half of the respondents were aware that serum potassium would reach its nadir at 60 minutes after insulin was administered and less than two-thirds indicated that they anticipated the potassium value to return to its pre-shift value. Only a third expected this to occur at 4–6 hours following insulin therapy.

“Of concern was the low expectation of hypoglycemia by respondents, with only 14% anticipating hypoglycemia between 2–3 hours after insulin had been administered and 22% indicating that hypoglycemia was uncommon if dextrose was co-administered. Only 30% checked the glucose concentration in the blood at two hours, and only 22% at three hours.”

Hyperkalemia: Treatment Recommendations

Based on the knowledge gaps that they have identified, the researchers make a few recommendations that could help medical specialists in the treatment and management of hyperkalemia.

They say medical specialists should start therapy when potassium is higher or equal to 6 mmol/L or when they notice any degree of hyperkalemia that is accompanied by symptoms or ECG changes.

“An ECG should be performed on all patients. Calcium salts should be administered only when there are ECG changes. Calcium salts are used to protect the heart from the dangerous effects of hyperkalemia.

“Short-acting insulin should be administered as a push (bolus) of 10 units, intravenously. Lower doses (five units) should be considered in patients with chronic kidney disease and kidney failure.

“Patients should be monitored for symptoms of hypoglycemia, and serum glucose concentrations should be measured hourly for at least three hours and up to six hours following insulin-based therapy. The potassium concentration should be checked one hour following insulin-based therapy as this is when the nadir is expected.”

The researchers say their study emphasizes the need to address knowledge gaps, particularly around the optimal and safe use of insulin-based therapies. “Our findings and recommendations should be useful in informing the development of consensus guidelines and educational resources on hyperkalemia.”

Source-Eurekalert