New study brings hope that more donor lungs could be used in the future. The researchers investigated whether the treatment will have the same positive effects
BODE Score may Overestimate Mortality Risk in Lung Transplantation
BODE score helps to predict the disease condition. It is evaluated and validated for potential lung transplant in patients suffering with chronic obstructive pulmonary disease (COPD).
BODE score helps to predict the disease condition. It is evaluated and validated for potential lung transplant in patients suffering with chronic obstructive pulmonary disease (COPD).
‘The results show that the lung function was restored to a higher capacity than before thanks to the reduced levels of cytokines. We could also see that the lungs were functioning better after the transplant and that complications during the first 48 hours after transplant was reduced.
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”The results from our study indicate that a certain treatment can help us use a larger part of a donor lung, and that there is an improved outcome during the first two days after surgery”, says Sandra Lindstedt, senior consultant in thoracic surgery at Skåne University Hospital and adjunct professor at Lund University. In their study on pigs, the researchers investigated the effects of reducing the levels of cytokines in lungs. Cytokines are small proteins that are produced by specific cells of immune system.
The function of the lungs was reduced before transplant so that the lungs developed acute respiratory distress syndrome (ARDS). By doing this, the lungs acquired injuries similar to those of donor lungs in humans. In ten cases the donor lung was treated – either before and after transplant or only after transplant. Six cases composed a control group and were not given any treatment.
Survival in Systemic Sclerosis Patients Following Lung Transplantation Evaluated in Large Study
Findings presented this week suggest that patients with end-stage lung disease due to systemic sclerosis should not simply be denied lung transplantation.
Findings presented this week suggest that patients with end-stage lung disease due to systemic sclerosis should not simply be denied lung transplantation.
”This will not work on all donor lungs but if we can use it on some of the donor lungs that are discarded today, it could be of great significance for patients on the waiting list for a transplant. We hope to create the needed prerequisites to save more patients”, Sandra Lindstedt says.
Lung Transplantation
To be able to conduct the study, a special unit was created within the Department of Cardiothoracic and Vascular Surgery, Anesthesia and Intensive Care at Skåne University Hospital. The unit brought together all the competencies needed for the study.Advertisement
Lung Transplantation is a Viable Treatment Option in End-Stage Lung Disease
Recent research has suggested that in the past five years, the number of lung transplantation surgeries has increased by about 20 percent.
Recent research has suggested that in the past five years, the number of lung transplantation surgeries has increased by about 20 percent.
The study results, which are published in Nature Communications, are the basis of a newly started clinical pilot study.
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Novel Device Help Kids With Severe Respiratory Failure Survive Until Lung Transplantation
With novel lung assist devices such as the Novalung, adults with end-stage respiratory failure and pulmonary hypertension requiring ECMO (extracorporeal membrane oxygenation) have been bridged toward lung transplantation.
With novel lung assist devices such as the Novalung, adults with end-stage respiratory failure and pulmonary hypertension requiring ECMO (extracorporeal membrane oxygenation) have been bridged toward lung transplantation.
Source-Eurekalert
